… Granulosa cells are crucial to the ovary, endocrine and reproductive … supraphysiological
doses of spermidine induce oxidative stress in mouse ovaries and apoptosis of granulosa cells …

… High doses of curcumin affect granulosa cells viability and hormonal function. … apoptotic
cell death as evidenced in some tumor cells. In this work, the effect of CUR on granulosa cells (…

… The higher concentrations were chosen in order to mimic supraphysiological … cell death in
cancer cells. Nevertheless, in our studies, we failed to notice COV434 apoptotic cell death as …

… Although no dose-response pattern was observed, we found increased levels of let-7g-5p in
… and procaspase-8 induces apoptosis in porcine granulosa cells, a key biological process in …

… However, apoptosis has not been reported in a human IVM embryo … apoptotic changes in
granulosa cells from immature follicles in women undergoing IVM. The incidence of apoptosis …

… When granulosa cell apoptosis was induced by high doses of dbcAMP in the present study,
… The dose of 5 mmol dbcAMP l–1 was supraphysiological (but not cytotoxic as shown by the …

… Apoptotic index of bovine granulosa cells (GCs) treated with melatonin in time- and dose-dependent
manners. Bovine GCs were cultured with various concentrations of melatonin for 24…

… According to our current understanding, supra-physiological levels of steroids produced by
… of the genes involved in cell survival/apoptosis and found out that anti-apoptotic Akt-1 and …

… , 200 μmol/l H 2 O 2 for 12 h was chosen as the treatment dose for subsequent experiments
(Fig. S1). Furthermore, the cultured GC treated with 200 μmol/ H 2 O 2 for 12 h exhibited …

… supra-physiological level of BPA (20 µg/ml) alters genes that are involved in cell cycle
progression, cell death and survival, apoptosis, … at a high and supra-physiological dose. Given the …