… unintentionally discovered that grapefruit juice interacts with certain drugs. The coadministration
of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can …

… Recently, a chance observation led to the finding that grapefruit juice can markedly increase
the oral bioavailability of a number of medications [1]. This article retraces discovery of this …

… The ultimate clinical consequences of enhanced drug bioavailability induced by grapefruit
juice would depend on the magnitude of the change relative to the therapeutic range for the …

… Inhibition of P-glycoprotein-mediated intestinal efflux was thought to contribute to the increase
in the bioavailability of the drug after grapefruit juice intake. One possible explanation for …

… However, in this study the drug was administered after an overnight fast … of bioavailability
of carbamazepine, a drug with a narrow therapeutic index, after consumption of grapefruit juice …

… Since drugs modifying gastric motility did not produce any significant effect on … grapefruit
juice. Many studies have demonstrated that grapefruit juice increases the bioavailability of drugs …

… between grapefruit juice and drugs. The causative substance(s) present in grapefruit juice
are … These results show that grapefruit juice increased the bioavailability of nitrendipine, and …

… We may in the future be able to harness the benefits of increases in drug bioavailability by
grapefruit juice through either standardizing the constituents or isolating the active ingredients…

… (Everfresh, Windsor, Ontario, Canada), 300 mL water, 1200 mL grapefruit juice (300 mL
grapefruit juice with drug followed by 150 mL every 0.5 hour until 3 hours after dosing), or 1200 …

… Coadministration of grapefruit juice and … on the bioavailability of each drug. This study
provides the opportunity to assess the effect of grapefruit juice on the disposition of these drugs. …