… GRHL3 methylation and the etiology of neural tube defects (… At last, grhl3 overexpression
and gene depletion experiments … The knockdown and overexpression of grhl3 in zebrafish …

… In summary, we have shown that mouse Grhl3 is essential for neural tube closure. The
human ortholog of this gene maps to chromosome 1p, and we have initiated a search for …

… a determinant of susceptibility to neural tube defects (NTDs), … and embryos, in which Grhl3
expression is reduced, display … congenic controls in which Grhl3 is unaffected. However, …

… allele of Grhl3. The functional role and downstream mediators of Grhl3 in neural tube closure
are … principally on the mammalian Grhl3 gene, and its particular role in neural tube closure. …

… The GRHL3 (grainyhead like transcription factor 3) gene is a mammalian homologue of
the transcription factor GRH, which was first identified in Drosophila as a protein-binding …

… Failure of neural tube closure leads to neural tube defects (… -like3 (Grhl3) is essential for
spinal neural tube closure, with null … ;Grhl3 +/- x Grhl3 f/- matings) did not indicate a major defect …

… DNM in PAX3 and two potentially causative missense DNMs in GRHL3 and PTPRS. … in
SHROOM3 and in PAX3 in trios affected with neural tube defects (NTDs). (A) Protein schematic …

… of human neural tube defects (… Grhl3 ct/ct hypomorphic embryos compared with Grhl3 ct/ct;
TgGrhl3/0 embryos that have mildly elevated Grhl3 expression, but a further increase in Grhl3 …

… Neural tube defects, including spina bifida, are among the most common birth … We first
chose the longest isoform 3 of GRHL3 for this assay. Surprisingly, isoform 3 failed to activate the …

… was to investigate the causes of spinal neural tube defects (NTDs), using the … Grhl3 expression,
the effects of Grhl3 overexpression were also investigated by intercrossing curly tail Grhl3…