Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-β
YQ Xiao, K Malcolm, GS Worthen, S Gardai… - Journal of Biological …, 2002 - ASBMB
… growth factor-β (TGF-β), which plays an important role in induction of an anti-inflammatory
phenotype and resolution of inflammation. In this study, we show that TGF-β … TGF-β selectively …
phenotype and resolution of inflammation. In this study, we show that TGF-β … TGF-β selectively …
Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
L Gorelik, RA Flavell - Nature medicine, 2001 - nature.com
… cells as a result of tumor growth have been shown to exert suppressive effects on the
immune system. Among such factors the most prominent is transforming growth factor-β (TGF-β). …
immune system. Among such factors the most prominent is transforming growth factor-β (TGF-β). …
… role of epidermal growth factor in transforming growth factor β (TGF-β) signaling and growth suppression: mediation by stabilization of TGF-β receptor type II
K Song, TL Krebs, D Danielpour - Journal of Biological Chemistry, 2006 - ASBMB
… -β receptors through unknown mechanisms. Here, we provide the first evidence that epidermal
growth factor (… of gene expression and growth suppression by TGF-β in LNCaP prostate …
growth factor (… of gene expression and growth suppression by TGF-β in LNCaP prostate …
The immune suppressive function of transforming growth factor-β (TGF-β) in human diseases
J Sheng, W Chen, HJ Zhu - Growth factors, 2015 - Taylor & Francis
Transforming growth factor-β (TGF-β) functions as an immune suppressor by influencing
immune cells’ development, differentiation, tolerance induction and homeostasis. In human …
immune cells’ development, differentiation, tolerance induction and homeostasis. In human …
… -like growth factor-I inhibits transcriptional responses of transforming growth factor-β by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of …
K Song, SC Cornelius, M Reiss… - Journal of Biological …, 2003 - ASBMB
… suppresses multiple TGF-β signals, using the NRP-152 epithelial cell line. We show that IGF-I
receptor signaling selectively suppresses the ability of TGF-β … TGF-β-induced transcription. …
receptor signaling selectively suppresses the ability of TGF-β … TGF-β-induced transcription. …
The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.
JD Gray, M Hirokawa, DA Horwitz - The Journal of experimental …, 1994 - rupress.org
… suppressive effects on the immune system (14). Recently, TGFfl has been reported to selectively
… Multiple suppressive effects of transforming growth factor 31 on the immune response in …
… Multiple suppressive effects of transforming growth factor 31 on the immune response in …
Transforming growth factor-β regulation of immune responses
… for TGF-β signaling, I-Smad7 suppresses TGF-β signaling … with a large number of other
transcription factors (51–53). To … Interestingly, a selective inhibitory function of TGF-β in NK …
transcription factors (51–53). To … Interestingly, a selective inhibitory function of TGF-β in NK …
Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
RH Chen, YH Su, RLC Chuang, TY Chang - Oncogene, 1998 - nature.com
… e ect, could not protect Hep3B cells from TGF-β-induced apoptosis. Furthermore, PD98059,
a selective inhibitor of MEK, did not suppress the antiapoptotic e ect of insulin. In contrast, …
a selective inhibitor of MEK, did not suppress the antiapoptotic e ect of insulin. In contrast, …
Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor β
RJ Coffey Jr, CC Bascom, NJ Sipes… - … and cellular biology, 1988 - Taylor & Francis
… effects of TGFjI and calcium on growth factor-inducible gene … and KC gene expression in
rapidly growing BALB/MK cells and … The suppressive effect of TGF, on mRNA levels is selective, …
rapidly growing BALB/MK cells and … The suppressive effect of TGF, on mRNA levels is selective, …
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
D Melisi, S Ishiyama, GM Sclabas, JB Fleming… - Molecular cancer …, 2008 - AACR
… Moreover, the secretion of TGF-β by pancreatic … suppress pancreatic cancer metastasis, we
determined the effect of the novel TβRI/II kinase selective inhibitor LY2109761 on the growth, …
determined the effect of the novel TβRI/II kinase selective inhibitor LY2109761 on the growth, …
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