… , which leads to fibrosis in the pathological milieu. This review describes the effect of TGF-β
signaling in fibrotic-associate lung, heart, liver, and kidney tissues, followed by a detailed …

… in tissue fibrosis, transforming growth factor (TGF)-β is considered a key molecule in the
activation of the fibrotic … of the role of TGF-β-mediated signaling pathways in the pathogenesis of …

… TGF-β signaling cascades are consistently activated in fibrotic tissues, regardless of the
etiology of the initial injury. Stimulation of TGF-β signaling not only requires de novo synthesis …

… Transforming growth factor-β (TGF-β) signaling … fibrotic TME in cancer. This review
systematically summarized the latest updates and discoveries of TGF-β signaling in the fibrotic TME. …

… ) as a key cytokine that initiates and terminates tissue repair and whose … of tissue fibrosis
2 . This review will explore the biology of tissue repair and the properties and actions of TGF-β …

… growth factor β (… -β signaling in models of pathologic tissue fibrosis. The cells targeted by
Pdgfb-Cre do not express the α v β 6 integrin, but express α v β 1 , α v β 3 , α v β 5 , and α v β 8 . …

… involved in the pathological increase of collagen expression in SSc have not been entirely
elucidated, extensive recent efforts have been devoted to study the role of TGF-β signaling …

… to the development of tissue fibrosis. The recent identification of Smad proteins, TGF-β
receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, has …

… These proteins include profibrotic proteins transforming growth factor-β (TGF-β) and
connective tissue growth factor (CTGF) and the antifibrotic proteins tumor necrosis …

… In summary, TGF-β signaling is the central player of fibrotic disease as it induces … as pro-fibrotic
factors secreted by non-fibroblasts. Canonical and non-canonical TGF-β components are …