… , in brain metastases particularly in relation to angiogenesis. We show that formation of brain
metastasis by metastatic … and that the growing brain metastases contain numerous enlarged …

… This review will outline general management of brain metastases and will focus on preclinical
findings regarding the radiosensitizing effect of small molecule HER2 targeting agents. …

… of brain metastasis growth. Approximately 50% of malignant brain tumors are intracranial
metastases… The distribution of metastases in the brain reflects a hematogenous route of spread, …

Lung cancer remains a leading cause of mortality with 1.69 million deaths worldwide. Activating
mutations in epidermal growth factor receptor (EGFR), predominantly exon 19 deletions …

… and metastatic breast cancers. HER2 positivity is a known risk factor for the development of
brain metastases. … with the brain as first site of recurrence, brain metastases are increasingly …

… in the brain, and breast cancer is the second most common cause of the development of
brain metastasis.1, 2 The most feared complication of breast cancer, brain metastasis develops …

… and documented measurable brain metastases. Prior local therapy to metastatic brain tumors,
… with asymptomatic or controlled symptomatic brain metastases by corticosteroid only were …

… of brain metastases. Overall survival from the time of diagnosis of brain metastases (BM-OS)
by epidermal growth factor … (B) development of brain metastases. EGFR mutant type (MT, …

… and size of metastases, prior therapy, and whether metastases are … imaging to screen for
brain metastases; clinicians should … the brain because of the high incidence of brain metastases …

… We reported previously that vascular endothelial growth factor isoform A (VEGF-A) expression
by Mel57 human melanoma cells led to tumor progression in a murine brain metastasis …