… one growth factor supplement is nec essary for growth (11-13). Exposure of a cell to one
growth factor can lower the threshold for mitogenicity of a second growth factor (14). Moreover, …

… The overall picture of IGF expression in rodents initially led to the concept of IGF-II as a
fetal growth factor and IGF-I as an adult growth factor. However, this expression pattern is not …

… hypoxia, and the secretion of the growth factors by the tumoral tissue and the stroma, leads
to activation of the receptors of the endothelial cell growth factors, and to an increasing of the …

… growth factors may be regulating the tumor growth, compared with the endothelial growth. …
important growth factors in primary breast cancer, based on differential expression of protein. …

… Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogenic
and migratory, and vascular permeability, factor. Although produced from the same gene at …

… GH may mediate its effects primarily through local production of insulin-like growth factor I (…
growth factor (EGF) family and transforming growth factor j3 (TGF/3) family of growth factors (5)…

… The FGFRs, which are phylogenetically closely related to the vascular endothelial growth
factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs), consist of …

The hormone-dependent human breast cancer cell line MCF-7 secretes transforming growth
factor-8 (TGF-p), which can be detected in the culture medium in a biologically active form. …

… growth factor families, their roles in tumor biology, as well as the respective downstream
signaling pathways. Importantly, cancer-… reliance of tumors on growth factors. On the other hand, …

… growth factors (TGF-ca). The clinical correlations with its expression were studied in 77 nonsmall
cell lung cancers … currently studying this approach in human non-small cell cancer lines. …