Vascular endothelial growth factor–targeted therapy in renal cell carcinoma: current status and future directions

BI Rini - Clinical Cancer Research, 2007 - AACR
… by angiogenic growth factors, such as vascular endothelial growth factor (VEGF), platelet-derived
growth factor (PDGF), and basic fibroblast growth factor (3). VEGF is the major factor

Biology and clinical development of vascular endothelial growth factor–targeted therapy in renal cell carcinoma

BI Rini, EJ Small - Journal of Clinical Oncology, 2005 - ascopubs.org
… vascular endothelial growth factor (VEGF) -directed agents in renal cell carcinoma. Bevacizumab
… VEGFR-2, vascular endothelial growth factor receptor type 2; PI3K, phosphoinositide 3-…

Vascular endothelial growth factor as prognostic factor in renal cell carcinoma

JAN Jacobsen, T Rasmuson, K Grankvist… - The Journal of …, 2000 - auajournals.org
growth factor (VEGF) has been recognized as an important constituent of vascularization
and growth of solid … findings and clinical outcome in patients with renal cell carcinoma (RCC). …

Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck

ME Sharafinski, RL Ferris, S Ferrone… - Head & neck, 2010 - Wiley Online Library
… Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important
therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the …

Quantitative immunohistochemical analysis of transforming growth factor‐α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head …

JR Grandis, MF Melhem, EL Barnes… - … Journal of the …, 1996 - Wiley Online Library
… patients, and squamous cell carcinomas) we were able to localize growth factor production
to specific epithelial cells (eg, basal, suprabasal epithelial cells, and tumor cells). The change …

Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma

M Maurizi, G Almadori, G Ferrandina… - British Journal of …, 1996 - nature.com
… Summary Epidermal growth factor receptor (EGFR) content was determined by a radioligand
receptor assay in 140 primary laryngeal squamous cell carcinomas (median value of 8.4 …

… , a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma

RJ Motzer, MD Michaelson, BG Redman… - Journal of Clinical …, 2006 - ascopubs.org
… Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor
growth factors: vascular endothelial growth factor (VEGF) and platelet-derived growth factor (…

Expression of vascular endothelial growth factor protein in human renal cell carcinoma

J Jacobsen, K Grankvist, T Rasmuson… - BJU …, 2004 - Wiley Online Library
growth factor, platelet derived growth factor, epidermal growth factor and vascular endothelial
growth factor (VEGF), the most potent mitogenic factor [1] In RCC it has been shown that up…

Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma

EM Messing - Cancer research, 1990 - AACR
… Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of
epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine …

Vascular endothelial growth factor expression is increased in renal cell carcinoma

D Nicol, SI Hii, M Walsh, B Teh, L Thompson… - The Journal of …, 1997 - Elsevier
cells resulting in cellular proliferation. Elevated levels of epidermal growth factor (EGF) and
basic fibroblast growth factor (… .3, 4 Although these growth factors are known stimulators of …