The biology of epidermal growth factor receptor in lung cancer

GV Scagliotti, G Selvaggi, S Novello, FR Hirsch - Clinical Cancer Research, 2004 - AACR
… The epidermal growth factor receptor is commonly overexpressed in non-small cell lung
cancer (NSCLC; reviewed in Ref. 5) and head and neck cancers (6). In NSCLC, overexpression …

Growth factor and peptide receptors in small cell lung cancer

TW Moody, F Cuttitta - Life Sciences, 1993 - Elsevier
cell lines have been established from lung cancer biopsy specimens. Numerous growth
factors and receptors have been identified in the small cell lung cancer (SCLC) cell lines. SCLC …

Epidermal growth factor receptors in non-small cell lung cancer

D Veale, T Ashcroft, C Marsh, GJ Gibson… - … journal of cancer, 1987 - nature.com
… -,B and is the receptor for a class of tumour growth factors (TGF-ca). The clinical correlations
growth factor receptor may play a part in the genesis or spread of lung cancers. This is the …

Epidermal growth factor receptor expression in human lung cancer cell lines

M Haeder, M Rotsch, G Bepler, C Hennig, K Havemann… - Cancer research, 1988 - AACR
Growth factor research and oncogene research are closely linked based on the hypothesis
of autocrine secretion; ie, cancer cells can produce and respond to their own growth factors (1…

Targeting the epidermal growth factor receptor in non-small cell lung cancer

RS Herbst, PA Bunn Jr - Clinical cancer research, 2003 - AACR
… The inhibition of tumor growth seen with EGFR-TK inhibition is also accompanied by … growth
factor (VEGF), basic fibroblast growth factor (bFGF), and TGF-α, all potent inducers of tumor

Epidermal growth factor receptor mutations in small cell lung cancer

A Tatematsu, J Shimizu, Y Murakami, Y Horio… - Clinical Cancer …, 2008 - AACR
… It is well known that epidermal growth factor receptor (EGFR) … in some patients with small
cell lung cancers (SCLC). In this … The vast majority of epidermal growth factor receptor (EGFR) …

Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer

KJ O'Byrne, MI Koukourakis, A Giatromanolaki… - … journal of cancer, 2000 - nature.com
… poor prognosis in non-small-cell lung cancer (NSCLC). Tumour cell vascular endothelial
growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) expression …

Human squamous cell lung cancers express increased epidermal growth factor receptors.

FJ Hendler, BW Ozanne - The Journal of clinical …, 1984 - Am Soc Clin Investig
… , epidermal growth factor; EGF-R 1, a murine monoclonal epidermal growth factor receptor-…
The present study examined human lung cancer biopsy specimens for the presence of EGF …

Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer

AB Sandler, DH Johnson, RS Herbst - Clinical cancer research, 2004 - AACR
… prognostic factor, whether basic fibroblast growth factor is a favorable prognostic factor, and
whether other surrogate clinical markers, potentially released by damaged endothelial cells, …

Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation

F Luppi, AM Longo, WI De Boer, KF Rabe, PS Hiemstra - Lung cancer, 2007 - Elsevier
… non-small cell lung cancer cells, involving transactivation of the epidermal growth factor receptor
(… a central role in regulating cell proliferation and it has been therefore implicated in lung