Nerve growth factor: early studies and recent clinical trials

ML Rocco, M Soligo, L Manni… - Current …, 2018 - ingentaconnect.com
… of pressure ulcers with nerve growth factor: a randomized clinical trial. Ann. Intern. … II trial
of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

MH Tuszynski, L Thal, M Pay, DP Salmon, HS U… - Nature medicine, 2005 - nature.com
… the brain itself) gene therapy, growth factors can be delivered directly to the brain and diffuse
for distances of 2–5 mm 7 . This clinical trial was undertaken based on extensive preclinical …

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

A Gualberto, M Pollak - Oncogene, 2009 - nature.com
… Here, we focus specifically on the available clinical trial and translational research data
concerning 12 of these compounds currently in clinical trials. The large number of trials planned …

Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions

A Morabito, E De Maio, M Di Maio, N Normanno… - The …, 2006 - academic.oup.com
growth and metastatic dissemination. The vascular endothelial growth factor (VEGF) family
of peptide growth factors … Several of these agents are currently in different phases of clinical

A phase I/II clinical trial to evaluate a combination of recombinant human platelet‐derived growth factor‐BB and recombinant human insulin‐like growth factor‐I in …

TH Howell, JP Fiorellini, DW Paquette… - Journal of …, 1997 - Wiley Online Library
… Comparative effects of platelet-derived growth factor, insulin-like growth factor, individually
and in … Plateletderived and insulin-like growth factors stimulate regeneration of periodontal …

Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial

M Simons, BH Annex, RJ Laham, N Kleiman, T Henry… - Circulation, 2002 - Am Heart Assoc
… The mode of growth factor delivery may alter its efficacy significantly. In a preclinical study, a
… of growth factors, 19 a feature not controlled for in this study. Nevertheless, the present trial

[HTML][HTML] Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure

R Hirschberg, J Kopple, P Lipsett, E Benjamin… - Kidney international, 1999 - Elsevier
… The negative results in this study are consistent with one other clinical trial of rhIGF-I in ARF.
Franklin et al, in a single-center study, administered rhIGF-I or placebo in random order to …

Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial

M Kitamura, K Nakashima, Y Kowashi, T Fujii… - PloS one, 2008 - journals.plos.org
… Preclinical evidence suggests that fibroblast growth factor (FGF)-2 can promote periodontal
… of factors such as platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF)-I …

Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia

H Shigematsu, K Yasuda, T Iwai, T Sasajima… - Gene therapy, 2010 - nature.com
… This outcome stands in marked contrast to reports on clinical trials of vascular endothelial
growth factor (VEGF), in which 60% of the patients developed edema. Such a difference …

A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee …

M Sánchez, N Fiz, J Azofra, J Usabiaga… - … : The Journal of …, 2012 - Elsevier
growth factors in stimulating tendon and synovial cell proliferation, migration, autocrine release
of hepatocyte growth factors … is a consistent clinical observation associated with the use …