Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon

F Del Gatto, R Breathnach - Molecular and cellular biology, 1995 - Taylor & Francis
… This inhibition can be overcome by mutating either the exon’s 5 or 3 splice site to make it
correspond more closely to the relevant consensus sequence. Two separate sequence …

Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 …

SJ Park, HT Kim, DH Lee, KP Kim, SW Kim, C Suh… - Lung cancer, 2012 - Elsevier
… an activating epidermal growth factor receptor (EGFR) … They received either erlotinib or
gefitinib once a day. Out of … tumors during their disease course, either whole brain radiotherapy or …

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

E Tischer, R Mitchell, T Hartman, M Silva… - Journal of Biological …, 1991 - Elsevier
growth factor (VEGF) is an apparently endothelial cell-specific mitogen that is structurally
related to platelet-derived growth factor… gene is split among eight exons and that the various …

[HTML][HTML] … gefitinib and erlotinib treatment in non–small-cell lung cancer patients harboring an epidermal growth factor receptor mutation in either exon 19 or 21

SH Lim, JY Lee, JM Sun, JS Ahn, K Park… - Journal of Thoracic …, 2014 - Elsevier
… A total of 375 patients with recurrent or metastatic stage IIIB/IV NSCLC, who had either exon
19 deletion or the L858R mutation in exon 21, and had received either gefitinib (n = 228) or …

Clinical course of patients with non–small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib

GJ Riely, W Pao, DK Pham, AR Li, N Rizvi… - Clinical cancer …, 2006 - AACR
… Seventy patients (24%) were found to have either EGFR exon 19 deletion or EGFR
L858R. The clinical characteristics of patients tested for EGFR mutations are listed in Table 1. …

Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non–small cell lung cancer patients treated with gefitinib or …

DM Jackman, BY Yeap, LV Sequist, N Lindeman… - Clinical Cancer …, 2006 - AACR
… The primary focus of this analysis is patients with either exon 19 deletions or L858R point
mutations. Table 1 shows the baseline characteristics of the patients found to have one of …

An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein

RP Carstens, EJ Wagner… - Molecular and cellular …, 2000 - Am Soc Microbiol
… IIIb and IIIc were transfected into DT3 and AT3 cells, we observed a predominant product
that consisted of either exon IIIb or exon IIIc spliced between the adenovirus upstream (U) …

Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations

YW Won, JY Han, GK Lee, SY Park, KY Lim… - Journal of clinical …, 2011 - jcp.bmj.com
… To evaluate clinical differences between the two most common EGFR mutations, we
retrospectively analysed RR and survival of advanced NSCLC patients harbouring either the exon

Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway

R Rosell, M Taron, N Reguart, D Isla, T Moran - Clinical cancer research, 2006 - AACR
… in a 2:1 ratio to receive either 150 mg of erlotinib daily or a … 90% of these mutations occur at
exons 19 and 21 near the ATP … The most common mutations in the EGFR gene are an exon

hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

DM Mauger, C Lin… - Molecular and cellular …, 2008 - Taylor & Francis
growth factor receptor 2 exon IIIc. In cells that normally include this exon, we show that the
overexpression of either hnRNP H1 or hnRNP F resulted in the dramatic silencing of exon IIIc. …