… the action of IGFBPs and their proteases to influence IGF action: (1) IGFBP binding to IGFs
… receptors and (2) cleavage of the IGFBPs into fragments with lower affinity to IGFs allows for …

… significance of IGFBP proteases in cellular growth regulation. … Similar kallikreins such as
gamma nerve growth factor (NGF) … of the acid-activated IGFBP protease, cathepsin D, and its …

… The IGF system is a complex network comprised of two growth factors (IGF-I and -II), cell …
proteins (IGFBP-1 to IGFBP-6), IGFBP proteases as well as several other IGFBP-interacting …

… proteases (ie serine, cysteine, aspartic and metalloproteases), investigators have characterized
IGFBP protease … and identification of several IGFBP proteases, the identity and functions …

… Although several well characterized serine proteases cleave IGFBP-4 or -5, the proteases …
IGFBP-5 protease degrades only IGFBP-5 and not other forms of IGFBPs, whereas proteases …

… the IGFBP-3 protease. We have also demonstrated recently a metallo/serine IGFBP-4 protease
in … to that for the IGFBP-4 protease in third trimester pregnancy serum. Whilst fragments of …

… of IGFBP-3, we assessed synovial fluid for IGFBP-3 protease activity (Fig. 4). Iodinated IGFBP…
fragments of IGFBP-3 of 22,20, and 17 kDa accounted for 60 ‘-t- 3% (mean t SD) of the total …

… -4) are considered, respectively, as stimulators and inhibitors of follicular growth and … on
IGFBPs expression and IGFBP proteolytic degradation in the ovary, with a focus on the protease, …

… Growth factor and IGFBP-proteolysis Proteolytic activity of cathepsin D against growth
factors and IGFBPs were measured by incubating 20,000–55,000 cpm of[ 125 I]IGFs, [ 125 I]PDGF-…

… Indeed, the addition of TIMP-1 to MC3T3-E1 conditioned media inhibited >85% of IGFBP-5
proteolytic activity, suggesting that MMPs were primary proteinases involved in the …