… IGFBP proteases in conditioned medium. Proteolytic activity has been described for IGFBP-…
In summary, the IGFBP-4 protease is a serine protease that degrades IGFBP-4 into non-IGF-…

… -like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. We
recently described a protease … by exposing pure IGFBP-4 to the protease to determine potential …

… proteolytic enzymes have been shown to cleave IGFBPs. … proteases serve a dual role in
the regulation of malignant proliferation and invasion. By cleaving IGFBPs, these proteases …

… out calpain-induced proteolytic studies on the insulin-like growth factor binding proteins …
other proteases. All IGFBPs, except IGFBP-6, are highly sensitive to proteolysis (the resistance of …

… in control patients, while the IGFBP-3 levels and the relative proportion of IGFBP-2 in peritoneal
fluid … However, IGF-II levels, IGFBP-4 profiles, and IGFBP-3 protease activity did not differ …

… IGFBP-3, as detected by Western ligand blot. To evaluate altered IGFBP profiles, we performed
IGFBP-3 protease … Although control urine had only minor protease activity (defined by the …

… growth factors (IGF-I and IGF-II), insulin-like growth factor binding proteins (IGFBPs), and
IGFBP proteases are involved in the regulation of somatic growth and cellular proliferation, in …

… IGFBPs can be degraded by a number of proteases, such as metalloproteinases. In
addition, the full-length peptides in biological fluids often contain fragments recognized by …

… cells both secrete a 92 kDa serine protease that cleaves IGFBP-5 into inactive fragments. …
In summary, insulin-like growth factor binding proteins are multifunctional proteins that provide …

… factors on the IGFBP-4IGFBP-4 protease system in hOB cells. We present evidence that
IGFBP-4 protease … abundant growth factors found in bone, IGF-II and transforming growth factor-…