… In this study, we have analyzed 1) whether IGFBP-3, IGFI, and IGF-II levels and IGFBP-3
protease activity are altered in the CSF of patients with leukemia, CNS tumor, or meningitis; and …

… cells both secrete a 92 kDa serine protease that cleaves IGFBP-5 into inactive fragments. …
In summary, insulin-like growth factor binding proteins are multifunctional proteins that provide …

… that one of the influencing factors in the activityofthis protease is the nutritional intake of the
… a similar protocol, but no proteolytic modification of any of the IGFBPs was found in any of the …

… functions as extracellular matrixdegrading enzymes, may potentially act as IGFBP
proteases involved in regulation of IGFs and IGFBPs during inflammation and wound healing. …

… from either hOB CM or human pregnancy serum with IGF-II did not lead to IGFBP-4 … between
IGF-II and IGFBP-4 is required for IGFBP-4 protease activity, we prepared IGFBP-4 mutants, …

… that IGFBPS protease activity … the IGFBP3-degrading proteases in human fibroblast-conditioned
medium (26), we were able to further characterize the IGFBP5-degrading protease …

… Therefore, we analyzed the binding affinity of bound and unbound IGFBP-rP1 forms for
these growth factors with the BIACORE instrument. In this assay, insulin or IGF-1 was …

… The insulin-like growth factors (IGFs), insulin-like growth factor binding proteins (IGFBPs),
and the IGFBP proteases are involved in the regulation of somatic growth and cellular prolif…

… protease inhibitors in the incubation mixtures. These data indicate that the major serum
IGFBP … serum protease activity that is specific for IGFBP-3. {Endocrinology 127: 2270-2280,1990) …

… However, we have shown that in this RIA the proteolytic clipping of IGFBP-3 results in an …
modified IGFBP-3. Our demonstration that protease activity alters the immunoreactivity of IGFBP-…