… , activation of latent complexes of transforming growth factor β. In effect, this process allows
integrins on one cell to activate … Integrin-mediated TGFβ activation has been shown to play …

A subset of integrins function as cell surface receptors for the profibrotic cytokine transforming
growth factor-β (TGF-β). TGF-β is expressed in an inactive or latent form, and activation of …

… Here, integrins enhance growth factor–induced activation of … activate c-Jun N-terminal
kinase or activated protein 1 (AP1)–related growth promoting pathways via activation of integrin-…

… possibility that integrin-mediated activation of other RTKs, such as Met, PDGFR, or Ron, may
also contribute to integrin signaling. We have also observed adhesion-induced activation of …

… growth factor response is that the cell must adhere to the ECM. This implies that the signalling
pathways initiated by growth factor-… by which growth factors elicit changes in integrin-ECM …

… the activation of Ras in the integrin-mediated activation of … (Ras N17) to block the adhesion
activation of Erk1/2 (Clark and … that integrin mediated regulation of RTK activation occurs in …

… leukemia cells have shown that the NFkB transcription factor is activated in response to
integrin-ligati~n(~~). There seems to be a role for Syk, an integrin-responsive tyrosine kinase, in …

… Thus, we conclude that c-Src is crucial for integrin activation in response to growth factors
and have also demonstrated the intimate association of Src and integrin signaling. In fact, …

… platelet-derived growth factor receptor (PDGFR)-β and α5β1-integrin, which controls the …
-integrin-dependent phosphorylation of PDGFR-β in the absence of growth factor stimulation…

… integrin and growth factor pathways, and identify FAK as a key component of the integrin but
not the growth factor … in terms of specific activation of an integrin-mediated event. Therefore, …