The biology of epidermal growth factor receptor in lung cancer

GV Scagliotti, G Selvaggi, S Novello, FR Hirsch - Clinical Cancer Research, 2004 - AACR
The prognostic significance of epidermal growth factor receptor (EGFR) expression in lung
cancer and, more importantly, its ability to predict response to anti-EGFR therapies, are …

Epidermal growth factor receptor mutations in lung cancer

SV Sharma, DW Bell, J Settleman, DA Haber - Nature Reviews Cancer, 2007 - nature.com
… that target the epidermal growth factor receptor (EGFR) provide important insights for new
lung cancer therapies, as well as for the broader field of targeted cancer therapies. We review …

Epidermal growth factor receptor family in lung cancer and premalignancy

WA Franklin, R Veve, FR Hirsch, BA Helfrich… - Seminars in …, 2002 - Elsevier
… proteins, particularly overexpression of epidermal growth factor receptor (EGFR) family …
EGF and transforming growth factor alpha. Epidermal growth factor receptor overexpression is …

[HTML][HTML] Screening for epidermal growth factor receptor mutations in lung cancer

R Rosell, T Moran, C Queralt, R Porta… - … England Journal of …, 2009 - Mass Medical Soc
growth factor receptor (EGFR), PI3K, BRAF, and K-ras genes are generally nonoverlapping
and identifiable in approximately 40% of non–small-cell lung cancers… small-cell lung cancers. …

Epidermal growth factor receptors in non-small cell lung cancer

D Veale, T Ashcroft, C Marsh, GJ Gibson… - … journal of cancer, 1987 - nature.com
… Our results suggest thatepidermal growth factor receptor may play a part in the genesis or
spread of lung cancers. This is the third common primary carcinoma in which we have found a …

[HTML][HTML] Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update

G Bethune, D Bethune, N Ridgway… - Journal of thoracic …, 2010 - ncbi.nlm.nih.gov
… Mutations in epidermal growth factor receptor have been discovered in association with
some lung cancers. Lung adenocarcinomas with mutated epidermal growth

[HTML][HTML] Epidermal growth factor receptor inhibition in lung cancer: status 2012

FR Hirsch, PA Jänne, WE Eberhardt… - Journal of Thoracic …, 2013 - Elsevier
Lung cancer is the most common cause of cancer deaths. … However, with the understanding
of lung cancer biology, and … patients with non–small-cell lung cancer (NSCLC). Epidermal …

Targeting the epidermal growth factor receptor in non-small cell lung cancer

RS Herbst, PA Bunn Jr - Clinical cancer research, 2003 - AACR
growth seen with EGFR-TK inhibition is also accompanied by decreases in vascular endothelial
growth factor (VEGF), basic fibroblast growth factor (… inhibit tumor growth by interfering …

[HTML][HTML] Role of epidermal growth factor receptor in lung cancer and targeted therapies

TC Liu, X Jin, Y Wang, K Wang - American Journal of Cancer …, 2017 - ncbi.nlm.nih.gov
… In the current review, we propose to illustrate the role of EGFR group of growth factors in lung
cancer progression and metastasis. We will particularly emphasize upon the impact of well-…

Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies

FR Hirsch, GV Scagliotti, CJ Langer, M Varella-Garcia… - Lung cancer, 2003 - Elsevier
… in patients with lung cancer [4], [5… lung cancer. The gene mechanisms for the protein
expression will be discussed, and for the HER2, differences between lung cancer and breast cancer