The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

OE Pardo, J Latigo, RE Jeffery, E Nye, R Poulsom… - Cancer research, 2009 - AACR
… Our previous work showed that fibroblast growth factor-2 induces … growth factor receptor
(FGFR) inhibitor PD173074 blocks H-510 and H-69 SCLC proliferation and clonogenic growth in …

Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer

AB Sandler, DH Johnson, RS Herbst - Clinical cancer research, 2004 - AACR
… ), an inhibitor of the epidermal growth factor receptor, to patients with recurrent NSCLC. … as
a prognostic factor, whether basic fibroblast growth factor is a favorable prognostic factor, and …

Evidence for the epidermal growth factor receptor as a target for lung cancer prevention

F Lonardo, KH Dragnev, SJ Freemantle, Y Ma… - Clinical cancer …, 2002 - AACR
Growth factor deprivation was achieved by culture of BEAS-2B cells for 6 days in LHC-9
medium without added growth factors or hormones. Acute NNK exposure was for 24 h at a …

Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer

J Amann, S Kalyankrishna, PP Massion, JE Ohm… - Cancer research, 2005 - AACR
growth factor receptor (EGFR) is occasionally amplified and/or mutated in non–small cell lung
cancer (… We therefore investigated lung cancer cell lines for alterations in EGFR gene copy …

Epidermal growth factor receptor inhibitors: a new prospective in the treatment of lung cancer

M Tiseo, M Loprevite, A Ardizzoni - … Chemistry-Anti-Cancer …, 2004 - ingentaconnect.com
Growth Factor Receptor). The EGFR family is a group of four structurally similar growth factor
… , including EGF (Epidermal Growth Factor) and TGF (Transforming Growth Factor), allowing …

Epidermal growth factor receptor mutations in patients with non–small cell lung cancer

BE Johnson, PA Jänne - Cancer research, 2005 - AACR
… A year has passed since mutations of the tyrosine kinase domain of the epidermal growth
factor receptor (EGFR) were discovered in patients with non–small cell lung cancer (NSCLC) …

Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer …

G Fontanini, M De Laurentiis, S Vignati, S Chine… - … Association for Cancer …, 1998 - AACR
growth factors and of their specific receptors has been performed … Several peptide growth
factors that are locally … the EGF-bike growth factors, also regulate cancer development …

Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non–small-cell lung cancer: current knowledge and future directions

W Pao, VA Miller - Journal of Clinical Oncology, 2005 - ascopubs.org
Purpose Gefitinib and erlotinib are small molecules that selectively inhibit epidermal growth
factor receptor (EGFR) tyrosine kinase activity. When these drugs were introduced into the …

… of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor …

V Rusch, D Klimstra, E Venkatraman, PW Pisters… - … Association for Cancer …, 1997 - AACR
… The epidermal growth factor receptor (EGFR) and its ligand transforming growth factor (TGF)
alpha are hypothesized to form an autocrine growth loop in non-small cell lung cancer (…

[HTML][HTML] Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis

P Zhan, J Wang, X Lv, Q Wang, L Qiu, X Lin… - Journal of Thoracic …, 2009 - Elsevier
… on survival of patients with non-small cell lung cancer (NSCLC) and small cell lung
cancer (SCLC). However, VEGFC and vascular endothelial growth factor receptor 3 (VEGFR3)/flt-1 …