Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

H Shigematsu, AF Gazdar - International journal of cancer, 2006 - Wiley Online Library
Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor
(EGFR) gene in lung cancers have generated enormous interest, because they predict for …

Vascular endothelial growth factor expression and neovascularisation in non-small cell lung cancer

T Yano, S Tanikawa, T Fujie, M Masutani… - … Journal of Cancer, 2000 - Elsevier
… expression of vascular endothelial growth factor (VEGF) were investigated in 108 cases of
NSCLC by immunohistochemistry. The correlation between von Willebrand factor (vWf) and …

Epidermal growth factor receptor expression, signal pathway, and inhibitors in non–small cell lung cancer

PA Bunn Jr, W Franklin - Seminars in oncology, 2002 - Elsevier
lung cancers have aberrant production of multiple growth factors and aberrant expression
of multiple growth factor receptors.1, 2 The non–small cell lung cancers (NSCLCs) frequently …

Serum levels of vascular endothelial growth factor dependent on the stage progression of lung cancer

W Matsuyama, T Hashiguchi, A Mizoguchi, F Iwami… - Chest, 2000 - Elsevier
… andcoagulation-fibrinolysis factors in patients with advanced lung cancer, the association of
lung cancer. The measurement of serum VEGFlevels may be useful to evaluate lung cancer

[HTML][HTML] Epidermal growth factor-based cancer vaccine for non-small-cell lung cancer therapy

G Gonzalez, T Crombet, F Torres, M Catala, L Alfonso… - Annals of …, 2003 - Elsevier
… The role that growth factors and their receptors play in human cancer growth and … Our
approach consisted of active immunotherapy with the epidermal growth factor (EGF). Two pilot …

Vascular endothelial growth factor increased by pulmonary surgery accelerates the growth of micrometastases in metastatic lung cancer

Y Maniwa, M Okada, N Ishii, K Kiyooka - Chest, 1998 - Elsevier
growth factor (VEGF), also known as vascular permeability factor, in the recurrence of lung
… that VEGF may play an important role in the rapid growth of dormant lung micrometastases. …

[HTML][HTML] Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data

S Jorge, SS Kobayashi, DB Costa - Brazilian Journal of Medical and …, 2014 - SciELO Brasil
… Clinical and biological features associated with epidermal growth factor receptor gene
mutations in lung cancers. J Natl Cancer Inst 2005; 97: 339-346, doi: 10.1093/jnci/dji055. …

[HTML][HTML] The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data

L Liu, X Shao, W Gao, J Bai, R Wang, P Huang… - Journal of Thoracic …, 2010 - Elsevier
Introduction Human epidermal growth factor receptor 2 (HER2) is regarded as a poor
prognostic factor in many tumors. Conflicting data in many literatures were reported about the …

[HTML][HTML] Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy

AF Gazdar - Cancer and Metastasis Reviews, 2010 - Springer
Lung cancer is the leading cause of cancer-related deaths worldwide, … the USA, lung cancer
accounts for approximately 28% of all cancer-related deaths [2]. Non-small cell lung cancer (…

Targeting epidermal growth factor receptor: central signaling kinase in lung cancer

T Yoshida, G Zhang, EB Haura - Biochemical pharmacology, 2010 - Elsevier
… Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. …
-targeted agents including the epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-…