A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.

WJ LaRochelle, M May-Siroff, KC Robbins… - Genes & …, 1991 - genesdev.cshlp.org
Platelet-derived growth factor (PDGF) chimeras were used to map a domain responsible for …
All of these findings establish a new mechanism for stable growth factor presentation at the …

Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs

SH Song, MG Wientjes, Y Gan… - Proceedings of the …, 2000 - National Acad Sciences
… that chemoresistance is induced by extracellular factors in tumor-bearing organs. By … (aFGF)
and basic (bFGF) fibroblast growth factors in the conditioned medium (CM) of solid …

Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

BL Chan, MV Chao, AR Saltiel - Proceedings of the …, 1989 - National Acad Sciences
… -12 pheochromocytoma cells with nerve growth factor (NGF) … are similar to those of other
growth factors, such as insulin. We … and differentiative properties ofnerve growth factor (NGF; refs…

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action

R Cao, MA Björndahl, MI Gallego, S Chen, P Religa… - Blood, 2006 - ashpublications.org
… The growth of HGF-induced lymphatic vessels can be … lymphatic vessel growth through
an indirect mechanism. … that expresses HGF under the control of the whey acidic protein (…

Mechanism of phosphorylation of the epidermal growth factor receptor at threonine 669

JL Countaway, IC Northwood, RJ Davis - Journal of Biological Chemistry, 1989 - ASBMB
control of the phosphorylation state of the EGF receptor at threonine 669. The significance of
the … cation of a growth factor-stimulated threonine protein kinase to the mechanism of signal …

Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism.

PL James, CE Stewart, P Rotwein - The Journal of cell biology, 1996 - rupress.org
… with IGFBP-5 cDNAs under control of a constitutively active … HE involvement of growth factors
in the regulation of myoblast … Unlike most growth factors, the insulin-like growth factors (IGFs…

Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation

I Kratchmarova, B Blagoev, M Haack-Sorensen… - Science, 2005 - science.org
… largely controlled by various growth factors (7, 8). To study the effects of growth factors on
hMSC, … of EGF, PDGF, fibroblast growth factor (FGF), and nerve growth factor (NGF) on cellular …

Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation

Y Saito, J Haendeler, Y Hojo… - Molecular and cellular …, 2001 - Am Soc Microbiol
… Normal sheep IgG was used as a negative control for anti-EGFR (lane 5). Immunoblotting …
Normal rabbit IgG was used as a negative control for anti-PDGFβR. Immunoblotting was …

Studies on the mechanism of action of nerve growth factor

DB Hier, BGW Arnason… - Proceedings of the …, 1972 - National Acad Sciences
… with growth factor were enriched in neurotubule protein, as compared with untreated (control)
ganglia. Furthermore, studies with ganglia treated with both vincristine and growth factor

Molecular mechanism of mitogen action: processing of receptor induced by epidermal growth factor

M Das, CF Fox - Proceedings of the National Academy of …, 1978 - National Acad Sciences
An affinity labeling technique used previously for identification of a membrane receptor for
epidermal growth factor (EGF) was exploited to investigate the physiological fate of receptor …