… IL10 14 are able to modulate features of plaque stability, such as the amount of inflammation
… profound effect on plaque stability is CD40L. Besides a profound decrease in plaque area, …

… Increased immature neovessels contribute to plaque growth … and stable neovessel networks
to increase plaque stability. … endothelial growth factor-A (VEGF)-A, fibroblast growth factor …

… -β with plaque stability in the human … plaque stability would be of great importance for
developing new therapeutic strategies. One such pathway could be the transforming growth factor-…

Background Transforming growth factor beta (TGF-β) and matrix metalloproteinases-9 (MMP-9)
have been implicated in the pathogenesis of human atherosclerosis but their …

… growth factors, including platelet derived growth factor (PDGF) and basic fibroblast growth
factor (… In the atherosclerotic plaque these growth factors are produced by ‘injured’ endothelial …

… plaque stability. Of course, translation of our findings to clinical studies to explore the use of
IGF-1 for plaque stability … is approved for human use for growth disorders in children and that …

… Thus, the mutual activation of T cells and macrophages results in production of various
cytokines and growth factors that stimulate VSMC proliferation, migration, as well as their …

… A, Connective tissue growth factor (CTGF) expression is higher in plaques from stroke
patients … In addition, we show that CTGF is associated with stable plaque characteristics. …

… interact with and bind the growth factors TGF-β and fibroblast growth factor (FGF), respectively…
-1, -3 and -13, release these growth factors into the pericellular space. TGF-β and FGF can …

… We examined other parameters thought to reflect plaque stability in the mouse model. We
quantified endothelial density by immunohistochemistry at each timepoint. Despite increased …