… Growth factors are soluble effector molecules of cellular … Growth factor receptors therefore
play a key role in transmitting … growth factor receptor (EGFR) was one of the earliest growth …

… xenografts, and to prevent activation of the receptor tyrosine kinase.15, 16, … agent targeting
a growth factor receptor and the first demonstration of the antiproliferative effects of an agent …

… receptor and nonreceptor TK subfamilies including the platelet … growth factor receptor (PDGFR),
fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor (…

… Agents directed at epidermal growth factor receptor (EGFR) provide a good example of our
need to improve this selection process. On one hand, anti-EGFR agents … -EGFR agents with …

… Several of these agents have recently entered clinical trials in patients with cancer. … for a
transforming growth factor-α-epidermal growth factor receptor (TGFα-EGFR) autocrine growth …

… or an anti-vascular endothelial growth factor receptor agent [V]). After an initial core biopsy,
patients would be treated with H alone or in combination with the other study agents. A tumor …

… In an attempt to classify these antireceptor agents, we have grouped them by their degree
of receptor specificity (restricted to the EGFR or also inhibiting other ErbB kinases) and by their …

… may be useful as antitumor agents. The rationale for selecting growth factor receptors as
targets for anti-cancer therapy is compelling. Growth factors are required for cell proliferation in …

… growth factor receptor ligandtoxin and immunotoxin conjugates are novel drugs that
contain an EGFR ligand or an EGFR-binding antibody that is conjugated to a cytotoxic agent. …

… Potential targets for modulating epidermal growth factor receptor (EGFR) signalling pathways
currently being investigated as part of the development of potential new anticancer agents.[…