Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway
… The discovery of epidermal growth factor receptor (EGFR) mutations in never-smokers has
been … growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. …
been … growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. …
Clinical course of patients with non–small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
… ), mutations in the epidermal growth factor receptor (EGFR) … Experimental Design: In patients
with NSCLC, EGFR exon … % (43 of 70) had an EGFR exon 19 deletion. After treatment with …
with NSCLC, EGFR exon … % (43 of 70) had an EGFR exon 19 deletion. After treatment with …
Comparison of clinical outcomes of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations after tyrosine …
M Sheng, F Wang, Y Zhao, S Li, X Wang… - European journal of …, 2016 - Springer
… Exon 19 deletion and exon 21 L858R mutation were the most common epidermal growth
factor receptor (EGFR) mutations. We examined the clinical impact of these two mutations in …
factor receptor (EGFR) mutations. We examined the clinical impact of these two mutations in …
Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
JY Wu, SG Wu, CH Yang, CH Gow, YL Chang… - Clinical Cancer …, 2008 - AACR
… in exon 20 of epidermal growth factor receptor (EGFR) are limited. To increase understanding
of the influence of exon … exon 20 mutations and analyzed the gefitinib treatment response. …
of the influence of exon … exon 20 mutations and analyzed the gefitinib treatment response. …
Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
… To better understand the patterns of resistance or response to EGFR TKIs of exon 20 insertion
mutations, we studied representative EGFR exon 20 mutations using in vitro systems. We …
mutations, we studied representative EGFR exon 20 mutations using in vitro systems. We …
Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations
YW Won, JY Han, GK Lee, SY Park, KY Lim… - Journal of clinical …, 2011 - jcp.bmj.com
… Deletion of exon 19 of the epidermal growth factor receptor (EGFR) and mutation of exon 21
… This study investigated the clinical impact of EGFR exon 19 deletion and L858R mutation by …
… This study investigated the clinical impact of EGFR exon 19 deletion and L858R mutation by …
Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: clinical outcomes and response to erlotinib
J Naidoo, CS Sima, K Rodriguez, N Busby, K Nafa… - Cancer, 2015 - Wiley Online Library
… Therapeutic targeting of epidermal growth factor receptor (EGFR) with EGFR tyrosine … In
particular, an EGFR exon 19 deletion (exon19del) and the L858R point mutation in exon 21 are …
particular, an EGFR exon 19 deletion (exon19del) and the L858R point mutation in exon 21 are …
Epidermal growth factor receptor exon 20 mutation in lung cancer: types, incidence, clinical features and impact on treatment
… treatment and outcome of epidermal growth factor receptor (EGFR) exon 20-mutated lung …
profile and survival of lung cancer patients with exon 20 mutations. We compared our results …
profile and survival of lung cancer patients with exon 20 mutations. We compared our results …
Prevalence of epidermal growth factor receptor exon 20 insertion mutations in non-small-cell lung cancer in Europe: a pragmatic literature review and meta-analysis
S Van Sanden, M Murton, A Bobrowska, N Rahhali… - Targeted Oncology, 2022 - Springer
… EGFR exon 20 insertion mutations are rare in NSCLC. There is a high unmet need in
patients with exon 20 insertions, including effective therapies. Prospective cohort studies are …
patients with exon 20 insertions, including effective therapies. Prospective cohort studies are …
Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non–small cell lung cancer patients treated with gefitinib or …
DM Jackman, BY Yeap, LV Sequist, N Lindeman… - Clinical Cancer …, 2006 - AACR
… KIT receptor and in the platelet-derived growth factor receptor-α. Following treatment with
imatinib, patients with exon … in survival compared with those with an exon 9 KIT mutation (19). …
imatinib, patients with exon … in survival compared with those with an exon 9 KIT mutation (19). …
相关搜索
- epidermal growth factor receptor exon
- growth factor receptor exon clinical course
- growth factor receptor mutations
- egfr exon growth factor receptor
- epidermal growth factor receptor kinase inhibitors
- epidermal growth factor receptor egfr mutations
- growth factor receptor gene complex mutations
- gefitinib or erlotinib growth factor receptor
- growth factor receptor pathway
- gefitinib treatment growth factor receptor
- growth factor receptor exon different efficacy
- growth factor receptor exon lung cancer
- tyrosine kinase domain growth factor receptor
- prolonged survival growth factor receptor
- characterization of epidermal growth factor receptor
- epidermal growth factor receptor activation