… The epidermal growth factor receptor (EGFR), a growth factor receptor involved in the
regulation of cellular differentiation and proliferation, is highly expressed by many tumor cells. In …

… vascular endothelial growth factor receptor 2 (VEGFR 2), also inhibits GBM tumour growth
in … (mTOR) inhibitor RAD001 (Novartis Pharma AG), AEE788 inhibits the phosphorylation of …

… -kDa type I transmembrane growth factor receptor located on the short arm of chromosome
7 [1]. As seen in Figure 1, EGFR binds to multiple ligands [EGF, transforming growth factor-α (…

… In this review we will focus on the main epidermal growth factor receptor inhibitors
demonstrating clinical benefit for colorectal cancer mainly cetuximab, panitumumab, erlotinib and …

Purpose JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor (FGFR)
tyrosine kinase inhibitor. This first-in-human study evaluates the safety, pharmacokinetics, …

… Epidermal growth factor receptor (EGFR) inhibitors are a new … Epidermal growth factor
receptor inhibitors and their role in … Epidermal growth factor receptor inhibition and non-small cell …

… Structure-based drug design was performed to design compounds able to interact with the
DFG motif; epidermal growth factor receptor (EGFR) was selected as an example. Structural …

… growth factor receptor (EGFR) inhibition, … inhibition associated cytokine production in
keratinocytes as well as in patients after treatment with epidermal growth factor receptor inhibitors …

The epidermal growth factor receptor (EGFR) is an important novel target for anticancer therapy.
In this study, we examined the molecular mechanisms that underlie the antitumor effects …

… A large body of experimental and clinical studies has provided evidence for a transforming
growth factor-α-epidermal growth factor receptor (TGFα-EGFR) autocrine growth pathway in …