… This review provides a mechanistic and clinical overview of agents that target the EGFR
with a view toward exploring the clinical implications of the differing specificities of the agents. …

… domain of the epidermal growth factor receptor(EGFR) gene occur in a subset of patients
with lung cancer showing a dramatic response to EGFR tyrosine kinase inhibitors. To gain …

… inhibitors (TKI) are not well clarified. They are uncommon EGFR mutations with unknown
clinical significance. … EGFR mutations of unknown clinical significance are heterogeneous and …

… to inhibit EGFR, gefitinib inhibits other tyrosine kinase receptors, including HER2 (Woodburn
et … This additional receptor activity may have clinical significance, and clinical studies in this …

… and has implications for current and future clinical research. Each of these 3 goals requires
specifically designed clinical trials that differ in terms of patient selection, clinical setting, and …

… growth factor receptor inhibitors shows that it can be difficult to predict differences in efficacy
between anti-receptor antibodies and small-molecule inhibitors (… Clinical implications of the …

… role in the process of tumor growth and metastatic dissemination. The vascular endothelial
growth factor (VEGF) family of peptide growth factors and receptors are key regulators of this …

… vascular endothelial growth factor receptor TKIs have been tested in the clinical setting over
… of more drugs. We review the latest results from clinical trials and the implications these …

… drugs targeting the fibroblast growth factor receptor (FGFR) signaling pathway have been
developed, including mostly tyrosine kinase inhibitors, selective inhibitors … clinical implications …

… between skin rash and the clinical outcome with each of these drugs. They highlight that, …
of the two drugs confer different pharmacodynamics with important clinical implications. They …