… [35] In summary, the role of single agent erlotinib as first-line therapy in patients with EGFR
wildtype NSCLC is not very well defined. On the basis of the randomized trial, single agent …

… growth factor (EGF) belongs to a family of related peptides (EGF-like growth factor), which
include transforming growth factor o (TGFo… EGF-like growth factors bind to activate one or more …

… for response include the presence of a rash, epidermal growth factor receptor expression
and mutation status. This article reviews the current clinical status of erlotinib. …

… growth; however, the mechanism of such an effect is not elucidated. Here, we demonstrate
that erlotinibinduced cell growth … role of p27KIP1 in G1/S arrest and cell growth inhibition by …

… Erlotinib (Tarceva) is a specific epidermal growth factor … Gefitinib (Iressa) shares with erlotinib
both a common chemical … 2-fold less potent than erlotinib. Clinical studies have resulted in …

… Erlotinib (Tarceva, R 1415, CP 358774, OSI 774, NSC 718781; Box 1 ) is … growth factor
receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor. Erlotinib …

… of erlotinib, an orally active inhibitor of epidermal growth factor … oral dose of [ 14 C]erlotinib
hydrochloride (100-mg free base … unchanged erlotinib, which demonstrates that erlotinib is …

… target for erlotinib, belongs to the human epidermal growth factor receptor (… erlotinib.
Extracellular binding of ligands like the epidermal growth factor (EGF) and transforming growth factor…

… erlotinib results in profound tumor growth inhibition when combined with radiation. cDNA
microarray analysis assessing genes differentially regulated by erlotinib … by erlotinib including …

… The situation has changed with capecitabine and erlotinib, … Erlotinib is a small molecule
tyrosine kinase inhibitor against epidermal growth factor receptor which has an important role in …