… growth factor (VEGF) as the major tumor angiogenesis factor, promoting tumor growth, …
Conversely, blocking of VEGF function inhibits angiogenesis and suppresses tumor growth …

… that involve the inhibition of the positive tumor angiogenic factors. These factors are
described beginning with the growth factors and cytokines followed by a variety of other positive …

… Hence, the molecular basis of tumor angiogenesis has been of keen interest in the field of
cancer research. The vascular endothelial growth factor (VEGF) pathway is well established …

… the tumor. This capillary proliferation is stimulated by a diffusible factor, tumor angiogenesis
factor, released by solid tumors, … The biology and isolation of tumor angiogenesis factor are …

… role in tumor angiogenesis, vascular endothelial growth factor is … role of VEGF in tumor
angiogenesis and the importance of … : Angiogenesis, bevacizumab, hypoxia-inducible factor, …

… by pro- and antiangiogenic factors and involves autocrine … Tumor angiogenesis is induced
by increased secretion of endogenous angiogenic factors or down-regulation of angiogenesis …

… Hypoxia inducible factor-1 alpha (HIF-1α) is a transcription factor that … angiogenesis,
tumor growth, and apoptosis in tumors that lacked HIF-1α (HIF-1α −/− ) and in wild type tumors…

Growth of solid tumors depends on angiogenesis, the process by which new blood vessels …
1 Tumors promote angiogenesis by secreting growth factors that stimulate endothelial …

… growth factor in the induction of tumor angiogenesis is well understood, the role of a second
group of angiogenic factors, the fibroblast growth factors (… function in tumor angiogenesis. …

… in promoting tumor angiogenesis and the … of angiogenesis and tumor growth in preclinical
models. In this review, we summarize the role of the VEGF pathway during tumor angiogenesis…