… cell growth, perhaps in concert with other growth factors such as bFGF (16). Tumor vessel
… this entire response without the need for tumor cells or exogenous growth factors (3). Thus, …

… xenografts in immunodeficient mice with the anti-VEGF monoclonal antibody A4.6.1 led to
reduced tumor vessel permeability and caused vascular regression. The reduced vascular …

… from destruction, 124 and VEGF dependence has also been shown in endothelial cells of
newly formed tumor vessels, but not that of the established tumor vasculature. This loss of …

… A variety of factors have been identified as potential positive regulators of angiogenesis: …
factors known as vascular endothelial growth factor (VEGF) or vascular permeability factor (VPF)…

… vessels into a more normal phenotype.32, 33 Considering the important role of VEGF and
… the changes in tumor vessels produced by agents that block the action of this growth factor. …

… of tumor vessels, there is a fraction of tumor vessels that have … human tumors contain a
significant fraction of vessels devoid … on vascular survival factors like VEGF, these vessels can be …

… , tumor progression represents the process of tumor growth occurring in conjunction with new
blood vessel … Tumor vessels often develop into disorganized bundles containing numerous …

… Vascular endothelial growth factor–induced tumor blood vessels are heterogeneous, of
at least 6 distinct types, and develop linearly over time. They include both angiogenic (mother …

… VEGF more precisely to the abluminal surface of the endothelial cell plasma membrane
and to VVOs (33), the function of which is up-regulated in the tumor vessels with recent tracer …

… the role of angiogenic factors in this process. The pro-angiogenic vascular endothelial
growth factors (VEGFs) and the angiopoietins are the only known growth factor families that are …