… by growth factors that interact with receptors localized at the plasma membrane. Most of these
receptors have a tyrosine kinase … The interaction of the growth factors with the receptors, …

… by cellular kinases. The tyrosine kinase receptors are essential for normal growth, …
Mutations that remove normal regulatory constraints on the ~ 290 amino acid kinase core of …

… stimulated by growth factors and their receptor tyrosine kinases. Growth factor binding to and
… The four canonical MAPK pathways are presented, although growth factors rarely activate …

… epidermal growth factor (EGF) receptor tyrosine kinase with a … tyrosine kinase and inhibited
other purified tyrosine kinases … potency over that of other tyrosine kinase inhibitors of four to …

… , and the degree of tyrosine kinase activity has been shown to … from tyrosine kinases in the
initiation, growth and metastases … the receptor tyrosine kinases is the epidermal growth factor …

… Trans-membrane receptor tyrosine kinases play an important role in the modulation of
growth factor signalling. The epidermal growth factor receptor (EGFR) is a member of a family of …

… A new class of protein tyrosine kinase inhibitors … the kinase activity of fibroblast growth factor
receptor 1 (FGFR1) and showed differential specificity toward other receptor tyrosine kinases…

… (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt … vascular
endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that …

… objective tumor regressions with epidermal growth factor receptor tyrosine kinases (EGFR
TKI) … Preclinical studies with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR …

… tyrosine kinase activity of the ppl40c"* NGF receptor is essential for the cellular actions of this
growth factor… of tyrphostins for inhibition of the tyrosine kinase activity of the NGF receptor …