… growth factors in growth and development is welI established. Like other multifunctional
growth factors, insulin-like growth factors I … In summary, the many recent advances in the basic …

… hormones (such as thyroid hormone, insulin, insulin-like growth factor 1 and vascular
endothelial growth factor) and mechanical forces that converge on a limited number of intracellular …

Publisher Summary This chapter discusses the role of transforming growth factor- α (TGF- α)
in the proliferation of the normal cells and its potential importance in tumor development. …

… We review basic aspects of the PDGF ligands and receptors, their developmental and
pathological functions, principles of their pharmacological inhibition, and results using PDGF …

Fibroblast growth factors (FGFs) signal in a paracrine or endocrine fashion to mediate a
myriad of biological activities, ranging from issuing developmental cues, maintaining tissue …

… Basic fibroblast growth factor (FGF-2) is a physiological relevant neurotrophic factor in the
nigrostriatal system and hence a promising candidate for the establishment of alternative …

… will focus on the basis of DF formation in women and discuss the physiological role of oocyte
… With respect to the latter, we will discuss a recently discovered insulin-like growth factor-4 …

… knowledge on the physiological and biological mechanisms of the bone remodeling process;
highlighting the role played by the regulating factors, in particular that of the growth factors. …

… basic biology of VEGF and its receptors and on their role in the regulation of physiological …
sufficient for endothelial cell growth; the role of mitogenic growth factors would be primarily to …

… In the recent decades, the molecular basis of angiogenesis, a new blood vessel formation …
of signaling systems, such as vascular endothelial growth factor (VEGF)-VEGFR, Angiopoietin-…