Growth, metabolism, and growth inhibitors of mesenchymal stem cells

D Schop, FW Janssen, LDS van Rijn… - … Engineering Part A, 2009 - liebertpub.com
cell growth, cell metabolism, and cell growth inhibition by metabolites for human MSCs for
five donors. During cultivation, the cell … Moreover, we evaluated the growth inhibitory effect of …

The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo

Y Lu, Y Yuan, X Wang, L Wei, Y Chen… - Cancer biology & …, 2008 - Taylor & Francis
… response to ConA stimulation test and T cell subsets analysis (FCM). … growth inhibitory
effect on murine tumor cell lines in vitro and inhibited the growth of ascitogenous hepatoma cells

Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

Y Hori, IC Rulifson, BC Tsai, JJ Heit… - Proceedings of the …, 2002 - National Acad Sciences
… multipotent cells. We report that treatment of mouse embryonic stem cells with inhibitors of
… signaling regulator, produced cells that resembled pancreatic β cells in several ways. These …

Ignored hallmarks of carcinogenesis: stem cells and cellcell communication

JE Trosko, CC CHANG, BL Upham… - Annals of the New …, 2004 - Wiley Online Library
cells are suppressed by either secreted negative growth … the stem cells) or GJIC (the early
initiated progenitor cells). Promoters inhibit either the secreted growth inhibitor to initiated stem

Normal stem cells and cancer stem cells: the niche matters

L Li, WB Neaves - Cancer research, 2006 - AACR
… However, Wnt inhibitors, including Dkk, sFRP, and Wif, have been found to be dominantly …
the stem cell niche in the hair follicle bulge, providing an environment of cell growth inhibition (…

Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth

R Ramasamy, EWF Lam, I Soeiro, V Tisato, D Bonnet… - Leukemia, 2007 - nature.com
… MSC, their growth was much faster as compared to the group receiving only tumor cells. To
… the ability to form a cancer stem cell niche in which tumor cells can preserve the potential to …

Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model

A Mohr, M Lyons, L Deedigan, T Harte… - Journal of cellular …, 2008 - Wiley Online Library
… , and murine embryonic stem cells expressing TRAIL have … growth in a mouse model and
to induce apoptosis in a relatively TRAIL refractory epithelial lung cancer cell line (A549 cells). …

ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells

DA Claassen, MM Desler… - Molecular reproduction …, 2009 - Wiley Online Library
… hES cells, ROCK inhibitors are likely to be useful when working with other human pluripotent
stem cells… In the past few years, several groups have reported the creation of iPS cells from …

Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition

NA Dallas, L Xia, F Fan, MJ Gray, P Gaur, G Van Buren… - Cancer research, 2009 - AACR
… relative to parental cells (P < 0.01) in vitro. Tumors derived from HT29/OxR cells showed
significantly greater growth inhibition in response to an IGF-IR mAb than did parental cells (P < …

Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation

G Forte, M Minieri, P Cossa, D Antenucci, M Sala… - Stem …, 2006 - academic.oup.com
… , can also modulate different biological responses in stem cells… -term exposure of mesenchymal
stem cells (MSCs) to HGF can … p38 inhibitor SB203580, while the effects on cell migration …