… genes for guanylyl cyclases, structure and function of the members of the guanylyl cyclase
family… A brief overview is presented of the downstream events controlled by guanylyl cyclases, …

… cyclic GMP. We then turned to the characterization of the enzyme that synthesized cyclic GMP
from GTP, guanylyl cyclase (… regulation of guanylyl cyclase and cyclic GMP functions. This …

… family of enzymes variously called guanyl, guanylyl or guanylate cyclases that catalyze the …
to cyclic guanosine monophosphate (cGMP) and pyrophosphate. Intracellular cyclic GMP is a …

… The known particulate guanylyl cyclases contain a single … protein kinase-like and cyclase
catalytic domains (Figure 1). Four … of cyclic GMP from guanylylcyclases or of cyclic AMP from …

… of ES cells into myocardial cells with NO donors and soluble guanylyl cyclase (sGC)
activators. Since NO–cGMP pathway exhibits a diverse role in cancer, we were interested in …

… by structural studies of the related soluble guanylate cyclase (sGC) protein, we proposed a
… two cyclase domains into an active conformation, enabling catalysis and cGMP synthesis (…

… of guanylate cyclase, thereby stimulating cyclic GMP accumulation. Guanylate cyclase-bound
haem serves as a transducer in transferring the signal from NO to guanylate cyclase…

… of intravascular cyclic GMP levels in vivo by activating sGC and inhibiting cyclic GMP break
down. … with elevated cyclic GMP levels, we determined the vascular cyclic GMP content under …

… elevated cyclic GMP in … guanylate cyclase (4-8). This report demonstrates for the first time
that an agent which specifically activates particulate guanylate cyclase elevates cyclic GMP in …

… called soluble guanylyl cyclases (sGC). NO-mediated activation of sGC leads to the synthesis
of the second messenger cGMP. In the intact striatum, transient elevations in intracellular …