The effect of dabigatran on haemostasis tests: a comprehensive assessment using in vitro and ex vivo samples

R Bonar, EJ Favaloro, S Mohammed, J Sioufi… - Pathology, 2015 - Elsevier
… surgical procedures, testing may be indicated. The aim of this study was to assess findings
of haemostasis laboratory tests for one of the DOACs, dabigatran (Pradaxa), tested across a …

Impact of dabigatran on a large panel of routine or specific coagulation assays

J Douxfils, F Mullier, S Robert… - … and haemostasis, 2012 - thieme-connect.com
… (s) should be used to measure the pharmacodynamic effects of dabigatran among a range
of routine or specific tests. Testing solutions of dabigatran used in this paper were chosen to …

Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays

TL Lindahl, F Baghaei, IF Blixter… - … and haemostasis, 2011 - thieme-connect.com
… and Quick PT INR>2 or Owren PT INR>1.5 over-dosing or accumulation of dabigatran
assay group, display variable effects at therapeutic concentrations of dabigatran. Some of these …

The effect of dabigatran on select specialty coagulation assays

DM Adcock, R Gosselin, S Kitchen… - American journal of …, 2013 - academic.oup.com
… In summary, dabigatran demonstrates an inhibitor effect in the hemostasis laboratory and
shows clinically significant interference in various clot-based and factor IIa–based chro-…

Impact of dabigatran on platelet function and fibrinolysis

AE Tsantes, E Kyriakou, S Bonovas… - Journal of the …, 2015 - Elsevier
… When we assessed the potential association between dabigatran levels (as determined by
the HTI assay) and hemostatic parameters, we detected very strong positive correlations with …

Global Thrombosis Test–a possible monitoring system for the effects and safety of dabigatran

K Otsui, DA Gorog, J Yamamoto, T Yoshioka, S Iwata… - Thrombosis …, 2015 - Springer
dabigatran might affect shear-induced thrombi (occlusion time [OT], sec) by the GTT, and to
investigate the possibility that the GTT could be useful as a monitoring system for dabigatran. …

The anticoagulant effect of therapeutic levels of dabigatran in atrial fibrillation evaluated by thrombelastography (TEG®), Hemoclot Thrombin Inhibitor (HTI) assay and …

S Solbeck, AS Jensen, C Maschmann… - … Journal of clinical …, 2018 - Taylor & Francis
hemostasis, may be used as a readily available screening test sensitive for the anticoagulant
effect of dabigatran … non-bleeding NVAF patients while displaying whole blood hemostasis. …

Dabigatran effects on the international normalized ratio, activated partial thromboplastin time, thrombin time, and fibrinogen: a multicenter, in vitro study

WE Dager, RC Gosselin, S Kitchen… - Annals of …, 2012 - journals.sagepub.com
… increasing dabigatran concentrations. Commercial TT methods were very sensitive to low
concentrations of dabigatran, with 9 of 10 reporting sites exceeding test limits at dabigatran

The effect of dabigatran on the activated partial thromboplastin time and thrombin time as determined by the Hemoclot thrombin inhibitor assay in patient plasma …

G Hapgood, J Butler, E Malan… - … and haemostasis, 2013 - thieme-connect.com
… of the effect of dabigatran on coagulation assays is based on the analysis of dabigatran-…
ex vivo samples (ie plasma from patients receiving dabigatran) in contrast to in vitro plasma …

The effect of dabigatran on thrombin generation and coagulation assays in rabbit and human plasma

C Zhang, P Zhang, H Li, L Han, L Zhang, X Yang - Thrombosis Research, 2018 - Elsevier
… with atrial fibrillation receiving dabigatran 110 mg twice … dabigatran and hemostatic situation
in “real life” patients with atrial fibrillation. To evaluate the antithrombotic effect of dabigatran