… extracellular matrix influence each of these cancer hallmarks and … We suggest that the success
of cancer prevention and … the evolving extracellular matrix, the tumor cells and its cancer‐…

… The extracellular matrix (ECM) is essential for cell support during homeostasis and plays
a critical role in cancer. Although research often concentrates on the tumor’s cellular aspect, …

… -less cancer evolution and purely epigenetic programming of hallmark cancer phenotypes
… , embodied in extensive alterations to the extracellular matrix (ECM) that envelop the cells …

… Integrins perform essential roles in cell adhesion to the extracellular matrix (ECM) and
much evidence suggests that interference with integrin-mediated adhesion can impair tumour …

… in cancer invasion. However, it remains unclear whether CAFs directly stimulate cancer cell
invasion or they remodel the extracellular matrix to … communication between cancer cells and …

… argues that all cancers share six common traits ("hallmarks") that … extracellular matrix
necessary to form new blood vessels increases the odds of metastasis. (See inflammation in cancer…

… introducing further hallmarks as the ability of cancer cells to … of cancer cells but instead must
include the study of tumor microenvironment and the contribution of extracellular matrix (ECM…

… In addition, the bioavailability of growth factors is regulated by sequestration in the pericellular
space and extracellular matrix, and by the actions of a complex network of proteases, …

… Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, …

… Here, we review evidence for the role of EVs in the establishment and maintenance of
cancer hallmarks, including sustaining proliferative signaling, evading growth suppression, …