Role of the tumor microenvironment in cancer hallmarks and targeted therapy

R Naser, I Fakhoury, A El-Fouani… - International …, 2023 - spandidos-publications.com
… solid tumors. These cellular and non‑cellular stromal components form the tumor
microenvironment (TME), which co‑evolves with tumor … to be among the distinctive hallmarks of …

[HTML][HTML] Metabolic hallmarks of tumor and immune cells in the tumor microenvironment

K Renner, K Singer, GE Koehl, EK Geissler… - Frontiers in …, 2017 - frontiersin.org
… supply and generation of building blocks for tumor growth but also contribute to … tumor
microenvironment is often based on the mutual metabolic requirements of immune cells and tumor

The tumor microenvironment shapes hallmarks of mature B-cell malignancies

KH Shain, WS Dalton, J Tao - Oncogene, 2015 - nature.com
… loss of heterozygosity of tumor-suppressor genes. However, it is critical to recognize that
even in the setting of a genetic disease, the B-cell/plasma cell tumor microenvironment (TME) …

Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment

JW Ivey, M Bonakdar, A Kanitkar, RV Davalos… - Cancer letters, 2016 - Elsevier
Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …

Hallmarks of cancer: new dimensions

D Hanahan - Cancer discovery, 2022 - AACR
… We further recognized that the tumor microenvironment (TME), herein defined to be composed
of heterogeneous and interactive populations of cancer cells and cancer stem cells along …

Tumor microenvironment indoctrination: an emerging hallmark of cancer

JG Goetz - Cell adhesion & migration, 2012 - Taylor & Francis
… that the corrupted tumor microenvironment becomes a full … tumor angiogenesis and
extracellular matrix remodeling. Nevertheless, the recent emergence of the tumor microenvironment

Key promoters of tumor hallmarks

K Mortezaee, J Majidpoor - International journal of clinical oncology, 2022 - Springer
… Evolution of tumor hallmarks is a result of accommodation of tumor cells with their nearby
milieu called tumor microenvironment (TME). Accommodation or adaptive responses is highly …

Hallmarks of cancer: interactions with the tumor stroma

K Pietras, A Östman - Experimental cell research, 2010 - Elsevier
… The stromal elements of tumors hold prognostic, … tumor microenvironment are continually
identified. Herein we review the current understanding of tumor cell interactions with the tumor

[HTML][HTML] Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks

A Peixoto, M Relvas-Santos, R Azevedo… - Frontiers in …, 2019 - frontiersin.org
… reflection in the glycoproteome is driven by microenvironmental cues and these events act
hallmarks, with emphasis on the crosstalk between glycans and the tumor microenvironment

[HTML][HTML] Imaging hallmarks of the tumor microenvironment in glioblastoma progression

JJ Walsh, M Parent, A Akif, LC Adam, S Maritim… - Frontiers in …, 2021 - frontiersin.org
… measures of tumor progression are only tumor size, we … tumor microenvironment that
were not solely related to the size of the tumor and changes might develop earlier during tumor