Statistical analysis of quality of life with missing data in cancer clinical trials

AB Troxel, DL Fairclough, D Curran… - Statistics in …, 1998 - Wiley Online Library
… We summarize issues that arise when considering quality of life (QOL) data in cancer clinical
trials, especially those related to missing data. We describe different types of missing data

Advanced Statistics: Missing Data in Clinical Research—Part 2: Multiple Imputation

CD Newgard, JS Haukoos - Academic Emergency Medicine, 2007 - Wiley Online Library
… and valid method for handling incomplete data in clinical research. This article will provide
a … for handling incomplete data (and how different methods may impact subsequent study

Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing data

S Wharton, A Astrup, L Endahl, MEJ Lean… - International Journal of …, 2021 - nature.com
trials; how approaches for handling missing data have evolved over the last decade; and
implications for interpreting clinical data … using the SCALE phase 3a clinical trial program as an …

Approaches for dealing with missing data in health care studies

KI Penny, I Atkinson - Journal of clinical nursing, 2012 - Wiley Online Library
Aim. The aims of this study were to highlight the problems associated with missing data in
healthcare research and to demonstrate the use of several techniques for dealing with missing

Dealing with missing outcome data in randomized trials and observational studies

RHH Groenwold, ART Donders… - American journal of …, 2012 - academic.oup.com
… decided to first evaluate methods to handle missing data in the absence of a treatment effect
(OR = 1). Additionally, we simulated a randomized trial with dichotomous outcomes and a …

Are we missing the importance of missing values in HIV prevention randomized clinical trials? Review and recommendations

O Harel, J Pellowski, S Kalichman - AIDS and Behavior, 2012 - Springer
… used for managing missing data in HIV prevention trials, we review the underlying assumptions
for managing missing data. Assumptions for managing missing values are built upon …

Intention‐to‐treat analysis with treatment discontinuation and missing data in clinical trials

R Little, S Kang - Statistics in Medicine, 2015 - Wiley Online Library
missing data.” We agree with the implication of this recommendation that current approaches
to handling missing data in clinical trials … likelihood methods to handle missing data, but the …

A review of the reporting and handling of missing data in cohort studies with repeated assessment of exposure measures

A Karahalios, L Baglietto, JB Carlin, DR English… - BMC medical research …, 2012 - Springer
missing data in cohort studies and the continuing use of inappropriate methods to handle
missing data … for authors so that the amount of missing data and how this was accounted for in …

Missing quality of life data in cancer clinical trials: serious problems and challenges

J Bernhard, DF Cella, AS Coates… - Statistics in …, 1998 - Wiley Online Library
… with missing data in cancer clinical trials’, Statistics in Medicine, 17, 653—666 (1998). 6.
Proceedings of the Workshop on missing data in quality of life research in cancer clinical trials: …

Standards should be applied in the prevention and handling of missing data for patient-centered outcomes research: a systematic review and expert consensus

T Li, S Hutfless, DO Scharfstein, MJ Daniels… - Journal of clinical …, 2014 - Elsevier
… [1] The purpose of the document was to provide 18 recommendations to address missing
data in clinical trials through careful trial design, conduct, and analysis. This document was …