… impact of IFN-α treatment on cccDNA transcription and HBV replication … IFN-α inhibits HBV
replication in our system and indicate that IFN-α lowers steady-state levels of HBV transcripts…

… IFN-a and IFN-g cDNAs, rSV40 vectors were used to test the responsiveness … IFN to HBV
and the ability of these IFNs to inhibit HBV transcripts and protein production and to activate IFN …

… NUCs inhibit reverse transcription and IFN-α stimulates HBV eradication by … of HBV DNA
replicative intermediates was more drastically reduced compared to the level of HBV transcripts …

… (F) Southern blot analysis of HBV replicative intermediates from HBV transfected-cells … to
IFN-α treatment. (G) Northern blot analysis of HBV transcripts isolated from HBV transfected-…

… Here, we aimed to screen for IFN-α subtype with the highest anti-HBV potency and to …
with the anti-HBV efficacy of IFN-α (7, 18), we next analyzed the transcription profile of IFN-induced …

… Although the presence of the HBV transcriptional template, the covalently closed circular
viral minichromosome (cccDNA) permits maintenance of infection in hepatocyte nuclei, viral …

… basics about HBV infection and interferon signaling. Next, we discuss mechanisms through
which HBV downregulates the function -activity and transcription- of the transcription factor …

… a better understanding of how suppressing HBV replication alters the IFNα triggered early
immunological events. We interrogated the transcriptional, serum cytokine/chemokine and …

… IFN- α subtypes with the highest anti- HBV potency and to characterize mechanisms of IFNα–
mediated HBV … ,(7,18) we next analyzed the transcription profile of IFN- induced genes: 319 …

… I IFNs on HBV replication in vivo. Our results indicate that IFN-α/β can suppress HBV replication
when … that IFN-α/β could also affect HBV RNA transcription or stability, as the reduction of …