… that regulate brain energy metabolism, how such mechanisms are altered during aging and
in neurodegenerative disorders, and the potential applications to brain health and disease …

… during normal aging. Hence, in our opinion, it is still unclear as to whether or not healthy
aging is truly associated with declining CMRg, and this remains an important issue to resolve. …

Cerebral metabolic rate of oxygen consumption (CMRO 2 ), cerebral … of healthy aging of the
brain. Although a frequent topic of study, changes of CBF and CMRO 2 during normal aging …

… When glucose/energy metabolism and its control of the aging brain is considered, in … and
mentally healthy senescent subjects a 23% reduction was found in the cerebral metabolic rate …

… the aging brain vulnerable to … brain aging, whereas lifestyles that include intermittent
bioenergetic challenges (exercise, fasting, and intellectual challenges) foster healthy brain aging. …

… While most studies have addressed changes in energy metabolism of the aging brain in …
to reveal metabolic changes that are taking place during the normal brain aging. The proteome …

… capacity of the aged brain to sustain … healthy aging is associated with a reduction in brain
cortical neuronal mitochondrial energy production and altered glial mitochondrial metabolism. …

… metabolic processes. The human brain is the prime controller of organismal metabolism, …
Brain metabolism requires the delivery of nutrients and energy fuel from outside [4,11,12,13,…

… aging, may be reflected in a deterioration in the capacity for oxidative metabolism, and further
loss of oxidative metabolism … We found that healthy aging was associated with a significant …

… developed to determine brain bioenergetics in aging brain. Here, we review the basic principle
of the imaging techniques and their utilization to monitor brain metabolism changes over …