Mechanisms of endothelial cell heterogeneity in health and disease

WC Aird - Circulation research, 2006 - Am Heart Assoc
endothelium in postcapillary venules regulates leukocyte trafficking; capillary endothelial
cells … , discontinuous endothelium in hepatic sinusoids); and endothelial cells from different …

Organ/tissue-specific vascular endothelial cell heterogeneity in health and disease

T Minami, M Muramatsu, T Kume - Biological and Pharmaceutical …, 2019 - jstage.jst.go.jp
… differentiated endothelial cells, in which heterogeneity has long … of vascular-bed heterogeneity
and characterization, this … -governed endothelial cell phenotypic changes. These involve …

New technologies with increased precision improve understanding of endothelial cell heterogeneity in cardiovascular health and disease

A Dawson, Y Wang, Y Li, SA LeMaire… - Frontiers in Cell and …, 2021 - frontiersin.org
Endothelial cell heterogeneity revealed by cell-specific sequencing. Endothelial cells (ECs)
exhibit phenotypic differences that stem from inherent organo-specific, vessel-specific, and …

Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives

LM Becker, SH Chen, J Rodor… - Cardiovascular …, 2023 - academic.oup.com
Endothelial cells (ECs) constitute the inner lining of vascular … diseases, thereby representing
realistic therapeutic targets. However, it has become evident that ECs are heterogeneous, …

Heterogeneity of vascular endothelial cells in normal and disease states

E Thorin, SM Shreeve - Pharmacology & therapeutics, 1998 - Elsevier
endothelium (see references above), none have focused on endothelial cell heterogeneity.
… what is known about heterogeneity among the endothelium within species. Furthermore, we …

Endothelial cell heterogeneity and plasticity in health and disease—new insights from single-cell studies

LM Becker, A Pasut, A Cuypers, P Carmeliet - The Vasculome, 2022 - Elsevier
… single-cell RNA sequencing (scRNAseq) studies, here we highlight two main examples of EC
plasticity and heterogeneity: (… in health and disease with a focus on metabolic plasticity and …

[图书][B] Endothelial cells in health and disease

WC Aird - 2005 - books.google.com
… that phenotypic heterogeneity is mediated, in … of endothelial cell biology-namely, in vitro
cell culture has fallen short in providing insight into the spatial and temporal dynamics of this cell

Endothelial cell heterogeneity

WC Aird - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
heterogeneity of endothelial cells during angiogenesis. For example, endothelial sprouts
comprise leading-edge tip cells followed by morphologically and functionally distinct stalk cells. …

Exploring the role of endothelial cell resilience in cardiovascular health and disease

Y Gao, ZS Galis - Arteriosclerosis, thrombosis, and vascular biology, 2021 - Am Heart Assoc
health. In this brief review, we applied this working definition of resilience to the endothelium
and its constitutive parts, the endothelial cells (… The contribution of endothelial heterogeneity

Vascular endothelial cell specification in health and disease

C Marziano, G Genet, KK Hirschi - Angiogenesis, 2021 - Springer
… Blood endothelial cell development … Each vessel type is lined with ECs that not only exhibit
a high degree of heterogeneity among different sections of the vascular tree, but also exhibit …