p38 MAPK pathway in the heart: new insights in health and disease

R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli. p38
… In this review, we summarize the current understanding of the role of the p38 pathway in …

[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases

A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
… The MKKK responsible for activating the p38 MAPK pathways appears to be cell type and …
of JNK pathway. In contrast, JIP4 appears to be a new component of the p38 MAPK pathway

Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
… Given all of the processes that p38 kinases can potentially control, dysregulation of this
pathway has been linked to several diseases, suggesting that pharmacological targeting of p38

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

AJ Muslin - Clinical science, 2008 - portlandpress.com
… research attempting to link these signalling pathways to cardiovascular disease. In the
present review, the role of the ERK, JNK and p38 MAPK cascades in the pathophysiology of …

MAP kinase pathways activated by stress: the p38 MAPK pathway

T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
… Furthermore, fibrillar β-amyloid, the major component of senile plaques in Alzheimer's
disease, can activate p38 MAPK in primary rat microglia and in human THP1 monocytes (163) . …

p38 signalling pathway

JJ Sanz-Ezquerro, A Cuenda - International Journal of Molecular …, 2021 - mdpi.com
… members of the p38MAPK pathways have joined the group of signalling pathways involved
in the development of neurodegenerative diseases, such as Alzheimer’s disease. In this …

p38 MAPK signalling cascades in inflammatory disease

E Herlaar, Z Brown - Molecular medicine today, 1999 - cell.com
… Neutrophils stimulated with IL-8 can activate both the ERK pathway, which is PI3K-dependent,
and the p38 MAPK pathway, which is PI3K-independent 24 . However, the majority of …

The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer

HY Yong, MS Koh, A Moon - Expert opinion on investigational …, 2009 - Taylor & Francis
… Here, we review the isoforms of p38 MAPK, activation and function of p38 MAPK signaling
… This review summarizes p38 MAPK inhibitors used for inflammatory diseases and cancer. …

p38 MAPK signaling in oral-related diseases

CS Patil, KL Kirkwood - Journal of dental research, 2007 - journals.sagepub.com
p38 MAPK signaling in chronic pain, temporomandibular joint disorders (TMJD), desquamative
disorders, … Finally, we will discuss p38 MAPK signaling and potential therapeutic targets. […

The regulatory roles of mitogen-activated protein kinase (MAPK) pathways in health and diabetes: lessons learned from the pancreatic β-cell

V Sidarala, A Kowluru - Recent patents on endocrine …, 2016 - ingentaconnect.com
… to target MAPKs in the treatment of various diseases is pro… Antioxidants inhibit JNK and p38
MAPK activation but not ERK 1/2 … transduction pathway for the treatment of various diseases. …