… The ER has evolved highly specific signaling pathways to ensure that its protein-folding
capacity is not overwhelmed. These pathways, collectively termed the unfolded protein response …

… proteins in the ER lumen. The ER has evolved highly specific signaling pathways called the
… protein response (UPR) to cope with the accumulation of unfolded or misfolded proteins. …

… and in disease. In the ER, the unfolded protein response (UPR) exerts an adaptive function
in protein quality control to ensure the proper synthesis, secretion, and correct folding of …

… on health. In this review, we focus on the mitochondrial unfolded protein response (UPR mt
), a response … heat shock response (HSR) and the unfolded protein response in endoplasmic …

… To alleviate the stress and restore homeostasis, the ER activates a signaling network
called the unfolded protein response (UPR). The UPR has three arms, which regulate protein …

… arms of the unfolded protein response (UPR) in response to … proteins PKR-like ER kinase
(PERK), IRE1α, and ATF6α. These sensors drive specific, coordinated and common responses …

… unfolded proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the
unfolded protein response … response pathways. The UPR has been implicated in a variety of …

… To escape such adverse conditions, ER activates stress sensor pathway termed as
unfolded protein response (UPR) through complex signaling network of Protein kinase R-like …

… tau localisation and its roles in health and disease. We include discussion of other … function,
activation of the unfolded protein response and defective protein degradation. It is important …

… turn out to be a cause or consequence of human disease. A number of diseases that result
from mutations in particular protein kinases and phosphatases are listed in Table1. However, …