… To achieve the optimal human health span, thriving research programs on stem cell medicine
targeting landmark clinical questions and longevity are essential. Some R2T examples are …

… proliferation, cell differentiation, and resilience) often do so … set of stem cell evaluations to
the area of muscle stem cells with … with other stem cells showing that muscle stem cells show a …

… We propose that the ability of stem cell EVs to extend life span and health span is through
modulation of senescence and, in particular, SASP that drives secondary senescence. …

… that hypothalamic stem cells modulate aging speed … the health span of an aged organism
has not been fully addressed. Here, we show that sEVs from young adipose-derived stem cells …

… that repeated treatment with stem cells in normal animals has antiaging potential, extending
health span and life span. Because antiaging and prolonged life span are issues currently of …

… , thereby contributing to longevity and health. Currently, an appealing option for … stem cell
transplantation (haHSCT), where healthy autologous bone marrow/peripheral blood stem cells …

… have a robust SASP, which can reinforce and spread senescence, locally and systemically,
inhibiting stem cell function and disrupting tissue homeostasis while increasing sterile …

… Similarly, stem cell-derived ß cell therapy for diabetes has been predicted to provide cost-benefit
over life-long insulin therapy within an 8-year horizon 92 . Notwithstanding, …

… to activate the stem cells that keep our other cells healthy. All these theories have merit, but
none of them alone is enough. To the degree that they’re true, they all drive aging together. …

… rather than later, improve health span and life span in humans. … stem cells or embryonic
stem cells, we could use these cells as alternative sources of hematopoietic stem/progenitor cells …