… We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal
… enzyme inhibitors and angiotensin receptor blockers. Methods and Results— Twenty healthy …

… I and Ang II levels in a dose-dependent manner when given orally to healthy humans (
37 ). … The human renin inhibitor aliskiren reduces complement C3c and C5b-9 in Ang II–induced …

… described renin inhibitors [24] . Aliskiren is one of the most potent inhibitors of human renin
… in plasma Ang II induced by specific inhibition of renin in monkeys [49] , sheep [50] , healthy …

… We examined the effect of the renin inhibitor, aliskiren, on … Aliskiren can provide additional
renin-angiotensin-aldosterone system inhibition and increases RBF in healthy individuals…

… renin inhibitors developed for the treatment of hypertension. The absorption, distribution,
metabolism, and excretion of [ 14 C]aliskiren were investigated in four healthy … and aliskiren …

… inhibitors emerged as an attractive option to inhibit the renin−… data with respect to the direct
renin inhibitor aliskiren given as an … analysing the effects of aliskiren on end-organ protection. …

… of the direct renin inhibitor aliskiren in healthy volunteers. Drug. Metab. … renin inhibitor
aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy …

… , the renin inhibitor Aliskiren dose-dependently decreases Ang II levels in humans following
… The aim of the study was to investigate in healthy volunteers the effect of repeated ingestion …

… Aliskiren is currently under evaluation by the Food … Aliskiren is a potent inhibitor of human
renin (IC 50 = 0.6 nM), 6,7 and studies in healthy human volunteers have shown that aliskiren …

… aliskiren in healthy individuals with mild to moderate hypertension. We compared the effects
of these various doses of aliskiren … of aliskiren and PRA at baseline and during treatment. …