… of the active metabolite in healthy subjects including nine poor metabolizers. We also
demonstrated that the pharmacokinetic parameters, AUC and C max of the active metabolite were …

… reduced formation of clopidogrel's active metabolite and reduced antiplatelet response as …
was conducted in healthy subjects. A pooled analysis of data from healthy subjects enrolled in …

… MI, metabolite in healthy subjects after single and multiple doses of rac-pazinaclone. … healthy
human subjects. Stereoselectivity was found in the intrinsic clearance of the MI, metabolite, …

… during chronic dosing to healthy subjects and the elderly … concentrations of the major
metabolite have been determined … of young healthy volunteers and an elderly group with arthritis. …

… and its oxidative and reductive metabolites in 16 healthy subjects. Hatched bars representing
… The mean total recovery of oxycodone and its metabolites for the 16 subjects was 72% ± 19…

… its active metabolite M1 obtained after administration of a single 8 mg oral dose of TCC to six
healthy subjects… Pharmacokinetic parameters of TCC and of its active metabolite M1 after a …

… of sibutramine and its active metabolites (desmethylsibutramine [M1] and didesmethylsibutramine
[M2]) was evaluated in 57 healthy subjects. Each subject received a single oral dose …

… rapid reduction to the active metabolite 10-hydroxy-… of OXC and its active metabolite,
on the otherhand, does not … 10-OH-CZ kinetics in healthy control subjects and in epileptic …

… Twenty healthy male subjects were recruited in this study and all provided written informed
… selexipag and 1.14 for its metabolite. Subjects were assessed to be healthy on the basis of …

… In the current study, prasugrel in healthy subjects produced a more consistent IPA response
than clopidogrel. Several hypotheses have been proposed to account for the interindividual …