Gap-junction channels dysfunction in deafness and hearing loss
… channels (gap junctions and hemichannels) may be targets for age-related hearing loss …
hemichannel-mediated ATP release and hearing controls in the inner earProc Natl Acad Sci …
hemichannel-mediated ATP release and hearing controls in the inner earProc Natl Acad Sci …
Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear
HB Zhao, N Yu, CR Fleming - Proceedings of the National …, 2005 - National Acad Sciences
… Connexin gap junctions play an important role in hearing … A gap junctional channel is formed
by two hemichannels. … membrane stress, and blocked by gap junctional blockers. We also …
by two hemichannels. … membrane stress, and blocked by gap junctional blockers. We also …
[HTML][HTML] Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death
M Cohen-Salmon, T Ott, V Michel, JP Hardelin… - Current Biology, 2002 - cell.com
… Similar hearing thresholds were measured in heterozygous and control mice. In contrast,
Cx26OtogCre mice showed a significant hearing loss, compared to heterozygous and control …
Cx26OtogCre mice showed a significant hearing loss, compared to heterozygous and control …
Key functions for gap junctions in skin and hearing
CA Scott, DP Kelsell - Biochemical Journal, 2011 - portlandpress.com
… R75W, which segregated with PPK and deafness in a family but was also found in a control
(the hearing ability of whom was unknown), failed to form functional channels and acted in a …
(the hearing ability of whom was unknown), failed to form functional channels and acted in a …
[HTML][HTML] Connexins and gap junctions in the inner ear – it's not just about K+ recycling
DJ Jagger, A Forge - Cell and tissue research, 2015 - Springer
… highlighted involvement of gap junctions in the transfer of … hearing. Here, we summarise
the current knowledge about the molecular and functional properties of inner ear gap junctions, …
the current knowledge about the molecular and functional properties of inner ear gap junctions, …
Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells
… We reveal a new efferent control pathway in which medial olivocochlear efferent fibers have
… to control their gap junctions, therefore regulating outer hair cell electromotility and hearing …
… to control their gap junctions, therefore regulating outer hair cell electromotility and hearing …
Molecular genetics of hearing impairment due to mutations in gap junction genes encoding beta connexins
… ties in gap junctions of the supportive cells of the cochlea are responsible for hearing
impairment in patients with connexin mutations. This anomaly in gap junctions is expected to …
impairment in patients with connexin mutations. This anomaly in gap junctions is expected to …
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea
DJ Jagger, A Forge - Journal of Neuroscience, 2006 - Soc Neuroscience
… Our results suggest that, by the onset of hearing, gap junctions between supporting cells
immediately adjacent to hair cells (Deiters’ cells, inner border cells) do not express Cx26-only …
immediately adjacent to hair cells (Deiters’ cells, inner border cells) do not express Cx26-only …
[HTML][HTML] Active cochlear amplification is dependent on supporting cell gap junctions
Y Zhu, C Liang, J Chen, L Zong, GD Chen… - Nature …, 2013 - nature.com
… hearing sensitivity and frequency selectivity. Here we describe the novel finding that gap
junctions … OHC electromotility to control active cochlear mechanics and hearing sensitivity. …
junctions … OHC electromotility to control active cochlear mechanics and hearing sensitivity. …
Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment
C Liu, B Tang, Q Pan, L Huang, H Dai, B Zhang… - Nature …, 1998 - nature.com
… hereditary hearing impairment, we cloned the gene ( GJB3 ) encoding human gap junction
protein β… Amplification in the absence of cDNA transcript was used as a negative control. RNA …
protein β… Amplification in the absence of cDNA transcript was used as a negative control. RNA …
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