Epigenetic-related therapeutic challenges in cardiovascular disease

C Schiano, MT Vietri, V Grimaldi, A Picascia… - Trends in …, 2015 - cell.com
challenges for therapeutic strategies in CVDs. We discuss the main epigenetic mechanisms
involved in atherosclerosis, coronary heart disease (CHD), HF, MI, and cardiac hypertrophy. …

Diagnostic and therapeutic challenges in patients with coexistent chronic obstructive pulmonary disease and chronic heart failure

TH Le Jemtel, M Padeletti, S Jelic - Journal of the American College of …, 2007 - jacc.org
Chronic obstructive pulmonary disease (COPD) and heart failure (CHF) are common conditions.
The prevalence of COPD ranges from 20% to 30% in patients with CHF. The diagnosis …

[HTML][HTML] Hypertensive Heart Disease—From Pathophysiology to Therapeutical Challenges

AS Vischer, T Burkard - Journal of Clinical Medicine, 2022 - mdpi.com
… The prevalence of hypertensive heart disease (HHD) has increased over the last … this disease
[1]. Furthermore, AHT remains the most important risk factor for ischemic heart disease with …

Anti-inflammatory therapy in chronic disease: challenges and opportunities

I Tabas, CK Glass - Science, 2013 - science.org
… In these diseases, the precise identity of the … in therapeutically targeting the inflammatory
response. Although there has been success with anti-inflammatory therapy in chronic diseases

Toward microrna–based therapeutics for heart disease: The sense in antisense

E Van Rooij, WS Marshall, EN Olson - Circulation research, 2008 - Am Heart Assoc
… modulation of disease mechanisms. Here, we summarize current knowledge of the roles of
miRNAs in heart disease and consider the advantages and potential challenges of microRNA…

[HTML][HTML] miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J Jin, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Heart failure is the final manifestation of CVD and cardiac injury, as well as less common but
important etiologies including cardiomyopathies, valvular heart disease… -based therapeutics

RNA therapeutics in cardiovascular disease

T Lucas, A Bonauer, S Dimmeler - Circulation research, 2018 - Am Heart Assoc
… Whether lncRNAs can be therapeutically targeted in a comparable manner as … challenges
in using noncoding RNAs as therapeutic targets for the treatment of cardiovascular diseases. …

Hypertensive heart disease and myocardial fibrosis: How traditional Chinese medicine can help addressing unmet therapeutical needs

M Liu, X Long, J Xu, M Chen, H Yang, X Guo… - Pharmacological …, 2022 - Elsevier
… for the occurrence and development of ventricular dilatation and heart failure. MF is the
pathological basis of hypertensive heart disease (HHD), and blood pressure control is the key to …

The therapeutical effect of Chinese medicine for the treatment of atherosclerotic coronary heart disease

J Zhang, H Meng, Y Zhang, X Zhang… - Current …, 2017 - ingentaconnect.com
… Abstract: Coronary heart disease (CHD) is the leading cause … Finally, challenges and
opportunities facing application of … AS is the main cause of coronary heart disease (CHD), which …

[HTML][HTML] MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

E Van Rooij, EN Olson - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
… A major challenge for the future will be to identify the mRNA targets of the … for therapeutically
exploiting the biology of miRNAs in the settings of congenital and acquired heart disease, …