… ACE2 has been tested in phase I and II clinical trials without adverse effects while lowering
and increasing plasma angiotensin II … regulation of ACE2 and the role of the ACE2/Ang 1–7 …

… The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS
… Angiotensin-converting enzyme 2 (ACE2) and its product, angiotensin 1–7 (Ang-[1–7]), are …

… Based on the above, the level of ACE2 and/or Ang (1–7) in patients with heart failure
should be interpreted cautiously as these patients are on drug regimen that may alter these …

… and physiology of ACE2 and its critical role in diastolic and systolic heart failure. … Analysis
of angiotensin peptide processing in the intact heart showed that ACE2 is mainly responsible …

… In conclusion, in humans with heart failure, plasma ACE2 is associated with various clinical
… associated with ACE inhibitor and angiotensin-receptor blocker use. Plasma ACE2 protein …

… and growth inhibiting peptide angiotensin(1–7) [… of ACE2/Ang(1–7) in hypertension, heart
failure, and atherosclerosis. In this review, we aim to focus on the conceptual facts of the ACE2-…

… lead to progressive worsening in heart failure. A pathway involving angiotensin converting
enzyme 2 (ACE2) has the capacity to break down Ang II while generating angiotensin-(1–7) (…

… angiotensin (Ang) system (RAS) and the central protective role of the Ang-converting enzyme
(ACE) 2 (ACE2)/Ang 1-7 axis in heart failure… AT 1 R), whereas ACE2 drives the RAS toward …

… ACE2 is a key negative regulator of the renin-angiotensin system (RAS) where it metabolizes
angiotensin (… Both the prolonged activation of RAS and the loss of ACE2 can be detrimental …

… AngII is further metabolized to angiotensin 1–7 (… angiotensin peptides. We hypothesize that
a significant redistribution of tissue and soluble ACE and ACE2 occurs in human heart failure …