… , or both that impair the ability of the heart to fill or eject blood. Common causes … heart
failure with depressed systolic function rather than the less-defined condition of heart failure …

Congestive heart failure (HF) is a clinical syndrome, with hallmarks … basic science discoveries
into clinical therapies. Models of myocardial infarction/ischemia, ischemic cardiomyopathy, …

… It is an enormous privilege and honor to be asked to give the basic science lecture. Please
join … Our objective in dealing with surgical treatment of heart failure is to change the basketball …

… date failed to show benefit in heart failure patients. The Heart Failure Association of the
European … the issue of inflammation in heart failure from a basic science, translational and clinical …

… is important in the progression of heart failure and that inhibition of … Thus, the evolution of
treatment for chronic heart failure as a … of information from basic science to clinical investigation. …

… rationale for the use of β-blockers in heart failure. Basic science studies were reviewed to
provide an overview of the potential physiologic role of β-blockers in heart failure. Finally, …

… Although the development and progression of heart failure … that the syndrome of heart
failure cannot be simply and/or … of heart failure has given rise to the notion that heart failure …

… of heart failure (Section on Preventing Heart Failure in High-risk Groups). Continued support
is warranted for basic scientific … signatures in the blood of different types of heart failure. …

… clinical syndrome of heart failure, no single conceptual paradigm for heart failure has … heart
failure in precise mechanistic and/or clinical terms is that the clinical syndrome of heart failure …

… Although nuances and specific details may be controversial, 4 the broad definition from the
Heart Failure Society of America guidelines states the following: “In physiologic terms, HF is a …