The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension

HJ Bogaard, K Abe, AV Noordegraaf, NF Voelkel - Chest, 2009 - Elsevier
… a good recovery of the heart after lung … hypertension.7, 8 This review aims to summarize
the available literature on the development of failure of the pressure-overloaded right heart. With …

Molecular mechanisms in heart failure: focus on cardiac hypertrophy, inflammation, angiogenesis, and apoptosis

D Hilfiker-Kleiner, ULF Landmesser… - Journal of the American …, 2006 - jacc.org
… overload (ie, hypertension), myocardial ischemia or … Heart failure is a major health care
burden, and despite significant therapeutic advances, morbidity and mortality in heart failure

Molecular mechanisms of human hypertension

RP Lifton, AG Gharavi, DS Geller - Cell, 2001 - cell.com
… the molecular mechanisms that have been implicated in blood pressure variation in humans.
… The NHLBI twin study of cardiovascular disease risk factors methodology and summary of …

Insulin resistance and heart failure: molecular mechanisms

AR Aroor, CH Mandavia… - Heart failure clinics, 2012 - heartfailure.theclinics.com
… , hypertension, insulin resistance, and myocardial and renal abnormalities. CRS increases
the risk for the development of T2DM mellitus (T2DM) and renal and cardiovascular disease (…

Molecular mechanisms of right ventricular failure

S Reddy, D Bernstein - Circulation, 2015 - Am Heart Assoc
heart disease and in those with pulmonary hypertension. Standard heart failure therapies
have failed to … a divergence in the molecular mechanisms of RV versus LV failure. Although, on …

The molecular basis of myocardial hypertrophy and heart failure

O Ritter, L Neyses - Trends in molecular medicine, 2003 - cell.com
… clinical picture in hypertensive heart disease and failure is often compounded by coronary
heart disease, but we will disregard this. Histologically, four features define the failing heart: (1…

Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions

C Savoia, EL Schiffrin - Clinical science, 2007 - portlandpress.com
… risk of cardiovascular events in patients with hypertension [4–… hypertension, the
pathophysiology of cardiovascular disease … bridges several cardiovascular risk factors (eg …

Mechanisms and management of hypertensive heart disease: from left ventricular hypertrophy to heart failure

JL Izzo, AH Gradman - Medical Clinics, 2004 - medical.theclinics.com
… with ischemic heart disease and ultimately cause heart failure (HF… , and drug treatment of
hypertensive heart disease that is … , Evaluation, and Treatment of High Blood Pressure (JNC 7) [ …

[HTML][HTML] Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications

A Harvey, AC Montezano, RA Lopes, F Rios… - Canadian Journal of …, 2016 - Elsevier
… Aging is the primary risk factor underlying hypertension and incident cardiovascular disease
amplified by hypertension. Some recently characterized molecular mechanisms underlying …

The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment

M Volpe, M Carnovali, V Mastromarino - Clinical Science, 2016 - portlandpress.com
… and progression of heart failure (HF) has … hypertension in response to chronic hypoxia [106].
CNP also reduces pulmonary hypertension [107] and fibrosis [108] and this mechanism