It is well known that the natural history of chronic heart failure (CHF),regardless of age and
aetiology,is characterized by progressive cardiac dysfunction refractory to conventional …

… HCM, a major cause of sudden death in young and heart failure, is … heart failure and often
associated with sudden death. In addition, there are other clinical types of cardiomyopathy…

… elevated pulmonary pressures and right heart failure that predominantly affects females
of … Patients with PAH mostly present with signs of right heart failure such as fluid buildup, …

… systolic heart failure (… molecular pathways underlying HF pathogenesis. Although a number
of novel myocardial signaling effectors have been implicated as drivers of HF pathogenesis, 1…

… , evidence is also emerging for a similar role modulated by the Ca(2+)–calmodulin-dependent
protein kinase II (CaMKII) signalling molecule in ischaemic injury and heart failure [21]. …

… The Ca 2+ re-uptake channel SERCA-2a has long been implicated in the pathogenesis of
heart failure and has been the target of several clinical trials in HFrEF [34]. Normally, SERCA …

… Heart failure with preserved ejection fraction (HFpEF) is a … the outcome in a heart failure
with reduced ejection fraction … of these two types of heart failure and the diversity of the HFpEF …

… ABSTRACT Heart failure is considered an epidemic disease … , cellular, and molecular
mechanisms are activated and act as … determining factor in heart failure is its constant progression. …

… With respect to structural and functional cardiac disorders, chronic heart failure (CHF) is
classified into heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved …

… heart failure, including drug therapies, device therapies, and regeneration therapies. However,
as each of these heart failure … therapeutic strategies for heart failure in a fundamental way…