Mitochondria as a therapeutic target in heart failure

M Bayeva, M Gheorghiade, H Ardehali - Journal of the American College of …, 2013 - jacc.org
… Despite the significant therapeutic potential of MitoQ and other TPP-conjugated antioxidants,
there are limitations. The uptake of these compounds is governed by the mitochondrial …

[HTML][HTML] New targets for heart-failure therapy: endothelin, inflammatory cytokines, and oxidative stress

MM Givertz, WS Colucci - The Lancet, 1998 - thelancet.com
heart failure has occurred, there are only limited therapeutic … Although the initial insult to the
heart (eg, myocardial … function and no clinically detectable heart failure, over time there is a …

Heart failure in type 2 diabetes mellitus: impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies

HC Kenny, ED Abel - Circulation research, 2019 - Am Heart Assoc
… T2DM accounts for 90% to 95% of all diabetes mellitus cases, 4 for this reason, this
review will focus on pharmacological treatments for T2DM and their impact on heart failure (HF) …

Carvedilol: molecular and cellular basis for its multifaceted therapeutic potential

J Cheng, K Kamiya, I Kodama - Cardiovascular drug reviews, 2001 - Wiley Online Library
… Carvedilol is a unique cardiovascular drug of multifaceted therapeutic potential. Its major
molecular … of hypertension, ischemic heart disease, and congestive heart failure is based on a …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
… the therapeutic potential of iPSCs in animal models of HF. … the Minnesota Living with Heart
Failure Questionnaire. Although … are needed to evaluate the therapeutic potential of CDCs. …

[HTML][HTML] Inflammatory cytokines and chemokines as therapeutic targets in heart failure

A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
… A major obstacle that hampers development of new therapeutics in heart failure is the
pathophysiologic heterogeneity of the disease. The clinical syndrome of heart failure can be …

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the …

S Heymans, E Hirsch, SD Anker… - … of heart failure, 2009 - Wiley Online Library
Heart Failure Association of the European Society of Cardiology recently organized an expert
workshop to address the issue of inflammation in heart failure … as novel therapeutic targets …

Prospects for gene therapy for heart failure

RJ Hajjar, F del Monte, T Matsui… - Circulation research, 2000 - Am Heart Assoc
… pathogenesis of heart failure, prompt careful consideration of gene therapy for heart failure at
this … transport, show therapeutic promise in animal models of heart failure and in myopathic …

[HTML][HTML] Heart failure: diagnosis, management and utilization

AA Inamdar, AC Inamdar - Journal of clinical medicine, 2016 - mdpi.com
Heart failure can be classified as predominantly left ventricular, right ventricular or … status
of heart: heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced …

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

T Münzel, T Gori, JF Keaney Jr, C Maack… - European heart …, 2015 - academic.oup.com
… In the present review, we address the potential role of ROS in the … in heart failure (HF)
and their therapeutic targeting. We discuss possible mechanisms underlying the failure of …